山东大学：《口腔组织病理学》课程教学资源（课件讲稿）第十三章 口腔黏膜病 白斑

1901 SHANDONG UNIVERSITY 白斑 LuH山f

白 斑

( Definition】 1886年匈牙利皮肤病学家Erno Shimmer将口腔粘膜的白色突起性损 害或混浊不透明的发白区称为白斑。 Department of Oral Pathology, Shandong University

Department of Oral Pathology, Shandong University 2 【Definition】 1886年匈牙利皮肤病学家Ernö Shwirmmer将口腔粘膜的白色突起性损 害或混浊不透明的发白区称为白斑

o Oral leukoplakia is a white patch or plaque that cannot be rubbed off cannot be characterized, clinically or pathologically as any other disease ( WHO, 1978) o In general, the term leukoplakia implies only clinical feature and carries absolutely no histologic connotation Department of Oral Pathology, Shandong University

Department of Oral Pathology, Shandong University 3  Oral leukoplakia is a white patch or plaque that cannot be rubbed off, cannot be characterized, clinically or pathologically as any other disease. (WHO,1978)  In general, the term leukoplakia implies only clinical feature and carries absolutely no histologic connotation

Leukoplakia is a whitish patch or plaque that cannot be characterized, clinically or pathologically, as any other disease and it is not associated with any physical or clinical causative agent except the use of tobacco (The International Symposium, 1983) Department of Oral Pathology, Shandong University

Department of Oral Pathology, Shandong University 4  Leukoplakia is a whitish patch or plaque that cannot be characterized, clinically or pathologically, as any other disease and it is not associated with any physical or clinical causative agent except the use of tobacco. (The International Symposium, 1983)

Oral leukoplakia is a predominantly white lesion of the oral mucosa that cannot be characterized as any other definable lesion some oral leukoplakias will transform into cancer (The 2nd International Symposium in Sweden 1994 Department of Oral Pathology, Shandong University 5

Department of Oral Pathology, Shandong University 5  Oral leukoplakia is a predominantly white lesion of the oral mucosa that cannot be characterized as any other definable lesion; some oral leukoplakias will transform into cancer. (The 2nd International Symposium in Sweden, 1994 )

Leukoplakia idiopathic leukoplakia tobacco-associated leukoplakia Leukoplakic-like lesion associated with the known cause frictional keratosis Department of Oral Pathology, Shandong University 6

Department of Oral Pathology, Shandong University 6 Leukoplakia idiopathic leukoplakia tobacco-associated leukoplakia Leukoplakic-like lesion associated with the known cause frictional keratosis

cadence 10.47%(include smokers keratosis and frictional keratosis)(1980) Pre-cancerous lesion 3%-5%malignant transformation Department of Oral Pathology, Shandong University

Department of Oral Pathology, Shandong University 7 Incedence: 10.47% (include smoker’s keratosis and frictional keratosis) (1980). Pre-cancerous lesion 3%—5% malignant transformation

【 Etiology】 Etiology likely to be multifactorial Tobacco smoking or snuff dipping aLcohol Betel quid usage o Mutation of the p53 gene iDiopathic Department of Oral Pathology, Shandong University 8

Department of Oral Pathology, Shandong University 8 【Etiology 】 Etiology likely to be multifactorial Tobacco smoking or snuff dipping Alcohol Betel quid usage Mutation of the p53 gene Idiophathic

Clinical features) 白斑可发生在口腔各部位粘膜,以 颊、舌粘膜最为多见。男性较为多发 男女之比为13.5:1。白斑为灰白色或乳 白色斑块,边界清楚,与粘膜平齐或略 为高起,舌舔时有粗涩感。 Department of Oral Pathology, Shandong University 9

Department of Oral Pathology, Shandong University 9 【Clinical features】 白斑可发生在口腔各部位粘膜，以 颊、舌粘膜最为多见。男性较为多发， 男女之比为13.5 : 1。白斑为灰白色或乳 白色斑块，边界清楚，与粘膜平齐或略 为高起，舌舔时有粗涩感

Clinical features) 根据临床表现可分为 均质型 Homogeneous 非均质型 Non-homogeneous Department of Oral Pathology, Shandong University 10

Department of Oral Pathology, Shandong University 10 【Clinical features】 根据临床表现可分为 均 质 型 Homogeneous 非均质型 Non-homogeneous