浙江大学医学院：《人体解剖学》课程教学资源（PPT课件）骨骼肌 Skeletal Muscle

Skeletal Muscle 骨骼肌 XIA Qiang(夏强),PhD Department of Physiology Zhejiang University School of Medicine Tel:88206417,88208252 Email: xiagiangazju. edu.cn

Skeletal Muscle 骨骼肌 XIA Qiang (夏强), PhD Department of Physiology Zhejiang University School of Medicine Tel: 88206417, 88208252 Email: xiaqiang@zju.edu.cn

Copyright e The McGraw-Hill Companies, Inc, Permission required for reproduction or display. (a)Skeletal muscle (b) Cardiac muscle (c)Smooth muscle sTriations r Connective Intercalated disc ogen Muscle fibertissue Branching StriationsNucleus Muscle cells Skeletal muscle骨骼肌 Cardiac muscle心肌 Smooth muscle平滑肌

Skeletal muscle骨骼肌 Cardiac muscle 心肌 Smooth muscle平滑肌

A SKELETAL MUSCLE Myofibril Plasma membrane (sarcolemma) TRIAD: Pla Z disk retculum cisterna membrane 000 Sarcomere Transverse Invaginations Invaginations of plasma Sarcoplasm membrane 0a0 reticulum (form trans cisterna verse tubules) Z disk D A-I band unctions Sarcoplasm reticulum B SMOOTH MUSCLE Caveolae :

Plasma membrane invaginations

Skeletal muscles connect are attached to the tissue skeleton by tendons. Blood Myofibril A band Iband Cross-bndge Thick(myosin) filament Thin(actin) filament Skeletal muscles typically contain many, many muscle fibers

Skeletal muscles are attached to the skeleton by tendons. Skeletal muscles typically contain many, many muscle fibers

Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display (b) H zone Z line Z line Titin Thin filament M line Thick filament The sarcomere(肌小节) is composed of: thick filaments called myosin, anchored in place by titin fibers, and thin filaments called actin, anchored to Z-lines

The sarcomere（肌小节） is composed of: thick filaments called myosin, anchored in place by titin fibers, and thin filaments called actin, anchored to Z-lines

Thick Thin filament filament °o8°。 。 A cross section through a sarcomere shows that: each myosin can interact with 6 actin filaments, and each actin can interact with 3 myosin filaments

A cross section through a sarcomere shows that: • each myosin can interact with 6 actin filaments, and • each actin can interact with 3 myosin filaments

Copyright e The McGraw-Hill Companies, Inc. Permission required for reproduction or display sarcomere i band- A band- H ZO Z line Z line Titin Thin filament M line Thick filament Sarcomere structures in an electron micrograph

Sarcomere structures in an electron micrograph

Myosin filaments Actin filaments Actin filaments Filaments Z disk k>disk AZOne AZOne I band A band i band-一 Sarcomere

Filaments

Myosin filament(thick filamen粗肌丝 > Myosin肌凝蛋白 Thick filament Myosin tail Myosin heads (cross bridges

 Myosin肌凝蛋白 Myosin filament (thick filament)粗肌丝

Actin filament (thin filament细肌丝 Actin肌纤蛋白 Tropomyosin原肌凝蛋白 Troponin肌钙蛋白 Tropomyosin Troponin complex G actin Thin filament

 Actin肌纤蛋白  Tropomyosin原肌凝蛋白  Troponin肌钙蛋白 Actin filament (thin filament)细肌丝