北京大学：《细胞生物学 Cell Science》课程教学资源（PPT课件讲稿）讲义

细胞科学 Science 蔡国平

细胞科学 Cell Science （11） 蔡国平

JJ-8v6 ut view oicu n a paiucuia position on DNA, a nucleosome remained fixed in place because of the tight association sequence-specific 30-nm 883 DNA-binding proteins nucleosome

H4 tail H2B tail H2A tail H3 tail H2A tail H4 t H2B tail Q要 H3 tail OSOMAL DNA AND ITS PACKAGING IN THE CHROMATIN FIBER

N side view histone H1

centrome-specific kinetochore protein centromere-specifi histone H3 proteins centromere-specific (B) conventional nucleosome histone H3

andard nucleosomes chromatin remodeling complex altered positioning remodeled nucleosomes

remodeling complex A restoration of standard nucleosomes dissociation addition of DNA-binding DNA-binding proteins remodeling GENE EXPRESSION, DNA REPLICATION, AND OTHER PROCESSES THAT REQUIRE ACCESS TO DNA PACKAGED IN NUCLEOSOMES

histone-fold domain N-terminal ta 9101418 unmodified gene silencing acetylated gene exprossion AC acetylated histone deposition methylated pene silencing heterochromatin phosphorylated mitosis/meiosis ⊙A corelated/ gene expression Me higherorder combinations acetylated histone deposition acetylated gene expresson

hi antiparallel 风 coiled coil m ATP 50 nm SMC dimer c/ chromatin Figure 4-56 The SMC proteins in condensins.(A)Electron micrographs of a purified SMC (B)The structure of an SMC dimer. The long central region of this protein is an antiparallel coile Figure l with a flexible hinge in ire middle ae domonerrared by the electron icrnnh in