复旦大学附属中山医院：《内科学》课程教学资源（PPT课件讲稿）血管炎病的诊断与治疗 Vasculitides

Vasculitides Fudan university Zhongshan Hospital Yuqiang

Vasculitides Fudan university Zhongshan Hospital Yuqiang

The term vasculitis refers to a heterogeneous group of disorders characterized pathologically by evidence of blood vessel inflammation and clinically by a diverse set of symptoms and signs

The term vasculitis refers to a heterogeneous group of disorders characterized pathologically by evidence of blood vessel inflammation and clinically by a diverse set of symptoms and signs

Pathology three types 1 necrotize 2. granulomas 3. only inflammatory cellular infiltration in the vessel wall

Pathology three types： 1. necrotize 2. granulomas 3. only inflammatory cellular infiltration in the vessel wall

Cause to 1. vessel wall angusty, blunting、 fibrosis, aneurysm 2 tissue ischemia, functional impalement

Cause to 1.vessel wall angusty， blunting、 fibrosis， aneurysm 2. tissue ischemia， functional impaiement

CLASSIFCATIO小 1. histopathologic (1) necrotize (2) granulomas (3) leucocytoclasia (4) giant cell

CLASSIFICATION 1. histopathologic （1）necrotize （2）granulomas （3）leucocytoclasia （4）giant cell

2. clinical classific ● infectivity ● un-infectivity

2. clinical classific • infectivity • un-infectivity

3. clinical+ histopathologic primarily skin systemIc secondary

3. clinical+ histopathologic primarily skin systemic secondary

Lie CLASSIFICATION primarily large-vessel Takayasu arteritis giant cell arteritis Medium-vessel polyarteritis nodosa Churg-Struss syndrom Wegener's granulomatosis small-vessel Microscopic polyangiitis Schonlein-Henoch syndrom

Lie CLASSIFICATION primarily large-vessel Takayasu artertis giant cell artertis Medium-vessel polyarteritis nodosa Churg-Struss syndrom Wegener’s granulomatosis small-vessel Microscopic polyangiitis Schonlein-Henoch syndrom

Secondary infectivity drug connective tissue disease associated with tumer

Secondary infectivity drug connective tissue disease associated with tumer

pog9门9s 1. infectivity 2. immune complex 3. antineutrophil cytoplasmic antibody ANCA-PR3 ANCA-MPO 4. antibody attack vessel AECA GBM antibody 5.cell immune 6. understand

pathogenesis 1. infectivity 2. immune complex 3. antineutrophil cytoplasmic antibody ANCA-PR3 ANCA-MPO 4.antibody attack vessel AECA GBM antibody 5.cell immune 6.understand