武汉大学生命科学学院：《分子生物学》英文版 Chapter 1 The Mendelian View of the World

Welcome each of You to My molecular Biology class @博来字 Wuhan University

Welcome Each of You to My Molecular Biology Class

Molecular Biology of the Gene, 5/E ---Watson et al. ( 2004) /Part I: Chemistry and Genetics Part: Maintenance of the Genome Part l: Expression of the Genome Part IV: Regulation Part v: Methods 3/01/05 Wuhan University

Molecular Biology of the Gene, 5/E --- Watson et al. (2004) Part I: Chemistry and Genetics Part II: Maintenance of the Genome Part III: Expression of the Genome Part IV: Regulation Part V: Methods 3/01/05

Question: Why Watson et al want to tell us some storie about genetics and chemistry before we start the molecular biology? 3/01/05

Question: Why Watson et al. want to tell us some stories about genetics and chemistry before we start the molecular biology? 3/01/05

Chemistry and Genetics Ch 1. The Mendelian View of the World Ch 2: Nucleic Acids convey genetic information Ch 3: The importance of weak chemical interactions Ch 4: The importance of high-energy bonds Ch 5: Weak and strong bonds determine macromolecular structure 3/01/05

Chemistry and Genetics Ch 1: The Mendelian View of the World Ch 2: Nucleic Acids convey genetic information Ch 3: The importance of weak chemical interactions Ch 4: The importance of high-energy bonds Ch 5: Weak and strong bonds determine macromolecular structure 3/01/05

Chapter 1: The Mendelian view of the World To explain how the genetic traits are transferred from the parents to the offsprings Two one person tell us one big story 3/01/05 Wuhan University

Chapter 1: The Mendelian View of the World To explain how the genetic traits are transferred from the parents to the offsprings Two + one person tell us one big story 3/01/05

Two important lessons to learn from Mendels discovery 1. The attitude to science interested in discovering the wonders of the nature( aws, mechanisms) 2.The principle to conduct science: I using simple models to understand the complicate or unknown Story 3/01/05

Two important lessons to learn from Mendel’s discovery 1. The attitude to science: interested in discovering the wonders of the nature (laws, mechanisms) 2. The principle to conduct science: using simple models to understand the complicate or unknown story 3/01/05

Discussion Why Mendelianism and darwinism conflicted initially, how the conflict was resolved?(P15-16 3/01/05

Discussion Why Mendelianism and Darwinism conflicted initially, how the conflict was resolved? (P15-16) 3/01/05

Chapter 2: Nucleic Acids convey genetIc inTormation The stories/efforts led to the fundamental knowledge of life, which open a new era of modern biology 3/04/05 Wuhan University

Chapter 2: Nucleic Acids convey genetic information The stories/efforts led to the fundamental knowledge of life, which open a new era of modern biology 3/04/05

Ch 2 Nucleic Acids convey genetic information Avery's Bombshell(1944) DNA can carry genetic specificity The Double Helix (1953 The genetic information within DNA is conveyed by the sequence of its four nucleotide building blocks The Central Dogma (1956) Establishing the direction of protein synthesis The Era of Genomics(2000) 3/04/05

Ch 2 Nucleic Acids convey genetic information Avery’s Bombshell (1944): DNA can carry genetic specificity 3/04/05 The Double Helix (1953) The genetic information within DNA is conveyed by the sequence of its four nucleotide building blocks Establishing the direction of protein synthesis The Central Dogma (1956) The Era of Genomics (2000)

Avery's Bombshell (1944) dNa can carry genetic specificity A story written for 26 years Thinking 1: what do you learn from the efforts of George W. Beadle and Edward Tatum(1940s), Frederick Griffith(1928), Osward T Avery (1940s)

Avery’s Bombshell (1944): DNA can carry genetic specificity A story written for 26 years Thinking 1: what do you learn from the efforts of George W. Beadle and Edward Tatum (1940s), Frederick Griffith (1928), Osward T. Avery (1940s)