麻省理工大学：《Systems Biology》L14: 14 Lectures past and 1 1 to go

L14: 14 Lectures past and 1 1 to go Part 'The cell as a well-stirred bioreactor topICs Lambda phage lysis-lysogeny switch Synthetic genetic switch Switches as memory storage Chemotaxis: perfect adaptation or not? Synthetic genetic oscillators main assumption Well-stirred reactor absence of chemical gradients (justification: small cells, diffusion mixes)

L14: 14 Lectures past and 11 to go Part I: ‘The cell as a well-stirred bioreactor’ 1 topics - Lambda phage lysis-lysogeny switch - Synthetic genetic switch - Switches as memory storage - Chemotaxis: perfect adaptation or not? - Synthetic genetic oscillators main assumption - well-stirred reactor - absence of chemical gradients (justification: small cells, diffusion mixes)

Switch from Systems Microbiology to Systems Cell Biology The importance of diffusion and gradients for cellular regulation

Switch from Systems Microbiology to Systems Cell Biology The importance of diffusion and gradients for cellular regulation 2

Part I: Systems Cell Biology Importance of gradients and diffusion In cellular regulation After two lectures on diffusion and reaction-diffusion equations We will focus during the coming lectures on the following biological systems 1. Eukaryotic chemotaxis Gradient sensing in Dictyostelium (aka' amoeba) 2. Computing the middle of a cell Pole-to-pole oscillations in Escherichia coll 3. Self organization of the cytoskeleton

Part II: Systems Cell Biology ‘Importance of gradients and diffusion in cellular regulation’ 3 After two lectures on diffusion and reaction-diffusion equations, we will focus during the coming lectures on the following biological systems: 1. Eukaryotic chemotaxis Gradient sensing in Dictyostelium (aka‘amoeba’) 2. Computing the middle of a cell Pole-to-pole oscillations in Escherichia coli 3. Self organization of the cytoskeleton