麻省理工大学：《Systems Biology》Systems Biology

Systems Biology

Systems Biology ?

Systems Biology x Network Biology GOAL: develop a quantitative understanding of the biological function of genetic and biochemical networks INPUT gene gene B gene C gene D gene E gene F OUTPUT function of gene product A-F can be known in detail but this is not sufficient to reveal the biological function of the inPUt-oUTPUt relation a system approach ( looking beyond one gene/protein) is necessary to reveal the biological function of this whole network what is the function of the individual interactions(feedbacks and feedforwards)in the context of the entire network?

Systems Biology ≈ Network Biology GOAL: develop a quantitative understanding of the biological function of genetic and biochemical networks gene A gene C gene E gene B gene D gene F INPUT OUTPUT - function of gene product A-F can be known in detail but this is not sufficient to reveal the biological function of the INPUT-OUTPUT relation - a system approach (looking beyond one gene/protein) is necessary to reveal the biological function of this whole network - what is the function of the individual interactions (feedbacks and feedforwards) in the context of the entire network ?

Alternatively, Systems Engineering Molecular biology Systems Engineering Molecular Biology Systems Biology Applying Systems Engineering concepts to Biological Systems

Alternatively, Systems Engineering + Molecular Biology Systems Engineering Molecular Biology Systems Biology = Applying Systems Engineering concepts to Biological Systems

molecular biology vs systems biology OR2 OR3 a traditional molecular biologist would ask: What is the molecular structure of the cl dimer what is dna sequence recognized by the cl dimer What are the essential amino acids in cl responsible for dimerization What are the values for k and K is the sequence conversed during evolution Focussed on the molecule cl

OR2 OR3 λ λ λ λ λ λ OR2 OR3 λ λ OR2 OR3 λ λ λ λ K1 K2 A traditional molecular biologist would ask: - what is the molecular structure of the cI dimer ? - what is DNA sequence recognized by the cI dimer ? - what are the essential amino acids in cI responsible for dimerization ? - what are the values for K1 and K 2 ? - is the sequence conversed during evolution ? Focussed on the molecule cI. molecular biology vs systems biology

molecular biology vs systems biology OR2 OR3 A systems biologist would ask What is the functional role of the feedback how can this lead to a hysteretic switch what is the role of noise in determining the stability of the switch is the performance of the switch sensitive to small changes in the parameters(fine-tuned)of not(robust how are these parameters changed when this module is cross-talking to other modules Focussed on the network architecture

OR2 OR3 λ λ λ λ λ λ OR2 OR3 λ λ OR2 OR3 λ λ λ λ K1 K2 A systems biologist would ask: - what is the functional role of the feedback ? - how can this lead to a hysteretic switch ? - what is the role of noise in determining the stability of the switch ? - is the performance of the switch sensitive to small changes in the parameters (fine-tuned) of not (robust). - how are these parameters changed when this module is cross-talking to other modules. Focussed on the network architecture. molecular biology vs systems biology

Goal of this course provide you with the essential mathematical tools to be able to model network modules, such as biological switches, oScillators, filters, amplifiers, etc provide you with lots of example of biological problems that can be successfully tackled with a systems biology approach(first well-stirred systems, second diffusion dominated systems)by discussing recentrecent papers

Goal of this course: - provide you with the essential mathematical tools to be able to model network modules, such as biological switches, oscillators, filters, amplifiers, etc. - provide you with lots of example of biological problems that can be successfully tackled with a systems biology approach (first well-stirred systems, second diffusion￾dominated systems) by discussing recent recent papers