上海交通大学：《医学微生物》课程教学资源（PPT课件讲稿）英文版 Hemorrhogic Fever Virus

Hemorrhogic Fever virus Hantaar Virus or HEMORRhaGic fever with renal syndrome virus( HFRS) Xing Jiang Hemorrhogic Fever Virus Dept of microbiology and parasitology

Hemorrhogic Fever Virus Dept. of microbiology and parasitology Hantaar Virus or HEMORRHAGIC FEVER with renal syndrome virus ( HFRS） Xing Jiang Hemorrhogic Fever Virus

Hantaan Virus (HEMORRHAGIC FEVER With renal syndrome virus

Hantaar Virus (HEMORRHAGIC FEVER with renal syndrome virus )

Morphology o Spherical 80-120nm o Nucleocapsid: Helical lpid envelope 3 segments, 2 proteins nucleocapsid (n), RNA polymerase (L) G2E o Envelope: 2 G1≥ glycoproteins, GI and 人‖ G2

 Spherical, 80-120nm  Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid ('N'), RNA polymerase ('L')  Envelope: 2 glycoproteins, G1 and G2, Morphology

Biological properties SSRNA with long, medium, short segments Antigens 6 serotypes (I-Vi) Resistance: weak BUNYAVIRUSES: ()senselambisense, 3 segments G2 NSm G1 M s Ns

Biological properties 1. ssRNA with long, medium,short segments 2. Antigens 6 serotypes (I- VI) 3. Resistance: weak

Epidemiology Natural host: rodents(deer mouse (Peromyscus maniculatus ), cotton rat (Sigmodon hispidus), marsh rice rat(Oryzomys palustris), white-footed mouse(Peromyscus leucopus), other carriers) Transmission: Droplet and rodent excreta spread 3 Season and district

Epidemiology 1. Natural host : rodents (deer mouse (Peromyscus maniculatus), cotton rat (Sigmodon hispidus), marsh rice rat (Oryzomys palustris) , white-footed mouse (Peromyscus leucopus), other carriers) 2. Transmission : Droplet and rodent excreta spread 3. Season and district

Clinical syndromes Pathogenicity Clinical manifestations Headache 5 phases o Pink in face. neck Fever phase ●上ever marked bleeding tendency Hypotension phase o Lower blood pressure Auria phase o Urine with protein Polyuria phase e multi-organ failure convalescent phase

Clinical syndromes  Headache;  Pink in face , neck  Fever  marked bleeding tendency  Lower blood pressure  Urine with Protein  multi-organ failure Pathogenicity Clinical manifestations: 5 phases  Fever phase  Hypotension phase  Auria phase  Polyuria phase  convalescent phase

o Pathogenesis o Viral direct damage ● Immunopathogenesis o Laboratory diagnosis o Cultivation: Vero-E6 cell and A549 cell Serological diagnosis: IgM/gg Indirect immunofluorescent assay ELISA-IgM o Inactivated vaccine

❑ Pathogenesis  Viral direct damage  Immunopathogenesis ❑ Laboratory diagnosis  Cultivation: Vero-E6 cell and A549 cell  Serological diagnosis: IgM/IgG indirect immunofluorescent assay ELISA-IgM ❑ Inactivated vaccine

Xing Jiang Hemorrhogic Fever Virus

Xing Jiang Hemorrhogic Fever Virus

o Spherical, 80-120nm Vector and Host Nucleocapsid: Helical, Animal Host 3 segments, 2 proteins Hyalomma asiaticum nucleocapsid(n), RNA polymerase(l") Season: April and may o Envelope: 2 o Inactivated vaccine glycoproteins, GI and G2

 Spherical, 80-120nm  Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid ('N'), RNA polymerase ('L')  Envelope: 2 glycoproteins, G1 and G2,  Vector and Host ➢ Animal Host ➢ Hyalomma asiaticum  Season: April and May  Inactivated vaccine