上海交通大学：《医学微生物》课程教学资源（PPT课件讲稿）第二讲 人畜共患病毒性疾病

flavivirus Xiao-Kui guo Dept of Microbiology and Parasitology

Flavivirus Xiao-Kui GUO Dept. of Microbiology and Parasitology

人畜共患病毒性疾病 Viral zoonosis 。人畜共患病 脊椎动物( vertebrate animals)所患疾病能通过 昆虫媒介直接或间接传递给人类 如果有昆虫参与,这个疾病也称为虫媒疾病 arboviraL) 如狂犬病、肾综合症出血热、流行性乙型脑炎和埃 博拉出血热

人畜共患病毒性疾病 Viral Zoonosis  人畜共患病 – 脊椎动物（vertebrate animals）所患疾病能通过 昆虫媒介直接或间接传递给人类 – 如果有昆虫参与，这个疾病也称为虫媒疾病（ arboviral） – 如狂犬病、肾综合症出血热、流行性乙型脑炎和埃 博拉出血热

虫媒病毒( Arthropod- borne viruses, arboviruses)是通过节肢动物( arthropod vectors)传播的病毒 o The who definition is as folllows Viruses maintained in nature principally, or to an important extent, through biological transmission between susceptible vertebrate hosts by haematophagous arthropods or through transovarian and possibly venereal transmission in arthropods

虫媒病毒（Arthropod-borne viruses， arboviruses）是通过节肢动物（ arthropod vectors）传播的病毒  The WHO definition is as follows – Viruses maintained in nature principally, or to an important extent, through biological transmission between susceptible vertebrate hosts by haematophagus arthropods or through transovarian and possibly venereal transmission in arthropods

虫媒病毒种类 虫媒病毒分属3个病毒科: Togaviruses(披膜病毒科) EEE WEE and vee Bunyaviruses(布尼亚病毒科) ° Haemorrhagic Fever Sandfly Fever, Rift Valley Fever, Crimean-Congo Flaviviruses(黄病毒科) Yellow Fever, dengue, Japanese Encephalitis

虫媒病毒种类  虫媒病毒分属3个病毒科： – Togaviruses （披膜病毒科） • EEE, WEE, and VEE – Bunyaviruses （布尼亚病毒科） • Haemorrhagic Fever • Sandfly Fever, Rift Valley Fever, Crimean-Congo – Flaviviruses （黄病毒科） • Yellow Fever, dengue, Japanese Encephalitis

Prevalence in China 。在我国流行并经病毒分离证实的虫媒病有6种 流行性乙型脑炎 森林脑炎 登革热 基孔贡亚热 肾综合征出血热 新疆出血热

 在我国流行并经病毒分离证实的虫媒病有6种 – 流行性乙型脑炎 – 森林脑炎 – 登革热 – 基孔贡亚热 – 肾综合征出血热 – 新疆出血热 Prevalence in China

Components in the Transmission and Maintenance of Arboviral Encephalitis PREDATORS VERTEBRATE HOSTS AND PARASITES FOODPACE RESOURCES VIRUS VIRUS WEATHER/ IMMUNE CLIMATE STATUS PREDATORS VECTORS AND DEAD END HOITS PARASITES FOOD/SPACE RESOURCES CDC

Scientist collecting specimens from trapped rodents

Scientist collecting specimens from trapped rodents

Common characteristics 40-70 nm in diameter, +SSRNA spherical enveloped Hemophilic arthropods as vector, and viruses replicate in arthropod o 5 type clinical manifestations and diseases related to season and district

Common characteristics  40~70 nm in diameter, +ssRNA spherical enveloped  Hemophilic arthropods as vector, and viruses replicate in arthropod  5 type clinical manifestations and diseases related to season and district

Major Clinical categories of arboviral D sease ● No clinical illness. Febrile systemic illness Encephalitis ● Haemorrhagic Fever. ● Hepatitis o arthritis

Major Clinical Categories of Arboviral Disease  No clinical illness.  Febrile systemic illness.  Encephalitis  Haemorrhagic Fever.  Hepatitis  arthritis

Genome FLAYTYIRUSES: ( +) sense, " 105kb 5 UTR Structural proteins Nonstructural proteins 3 UTR CAP

Genome