上海交通大学：《医学微生物》课程教学资源（PPT课件讲稿）英文版 Prevention and treatment

Rabies virus

Rabies virus

Shape: bullet a Genome -SSRNA enveloped virus CPE: Negri body

◼ Shape: bullet ◼ Genome: -ssRNA ◼ enveloped virus ◼ CPE: Negri body

Rabies Genome M 5 424 9105 165 12 kilobase

Structure of rabies virus Envelope (Membrane) Matriⅸ k Protein Glycoprotein G glycoprotein Ribonucleoprotein id bilayer membrane Cross Sectional helical nucleocapsid (RNA plus olymerase A Envelope (Membrane bilayer) Ribonucleoprotein Protein

Structure of Rabies Virus

抵抗力不强,60°C30min或100°C 2min可灭活。可被强酸、强碱、乙醇 乙醚、肥皂水、去垢剂等灭活 在脑组织中室温或4°C可持续1-2周 甘油中可保存数月

◼ 抵抗力不强，60C 30min或100C 2min可灭活。可被强酸、强碱、乙醇、 乙醚、肥皂水、去垢剂等灭活。 ◼ 在脑组织中室温或4C可持续1－2周。 甘油中可保存数月

Reservoir Urban forms: Dogs and cats Sylvatic forms: Bats, foxes raccoons莞熊, wolves skunks臭鼬, coyotes丛林狼 mongooses猫鼬 and biting animals

Reservoir ◼ Urban forms: Dogs and cats ◼ Sylvatic forms: Bats, foxes, raccoons莞熊, wolves, skunks臭鼬, coyotes丛林狼, mongooses猫鼬, and biting animals

Transmission By bite or scratch Via saliva Airborne( bats)

Transmission ◼ By bite or scratch ◼ Via saliva ◼ Airborne ( bats)

BAT armadillo

BAT armadillo

Cat fox raccoon dog

Cat fox raccoon dog

Rabies or hydrophobia Fever ■ Hydrophobia恐水 a Dysphagia咽下困难■ Hypersalivation Altered mental 多涎 status a Nausea Excitement vomiting恶心;作 agitation 区 Paralysis麻痹 Headach a malaise / G

Rabies or hydrophobia ◼ Fever ◼ Dysphagia咽下困难 ◼ Altered mental status ◼ Excitement, agitation ◼ Paralysis麻痹 ◼ Hydrophobia恐水 ◼ Hypersalivation 多涎 ◼ Nausea, vomiting恶心;作 呕 ◼ Headache ◼ malaise不适