复旦大学附属中山医院：《内科学》课程教学资源（PPT讲稿）於强 - Systemic Lupus Erythematosus（SLE）

Systemic Lupus Erythematosus Zhongshan Hospital 於强

Systemic Lupus Erythematosus Zhongshan Hospital 於强

Types of lupus ▲ Discoid ▲ Systemic ▲ Drug-induced

一. Types of lupus ▲ Discoid ▲ Systemic ▲ Drug-induced

Characteristic of disease Atuoimmune a Target tissue damage connection tissue(shin、 Joint、 muscles) A Predominantly population women during their reproductive year 90%0 A morbidity 70 per 100,000

二. Characteristic of disease: ▲ Atuoimmune ▲ Target tissue damage: connection tissue (shin、Joint、 muscles) ▲ Predominantly population： women during their reproductive year 90% ▲ morbidity：70 per 100，000

Pathogenic factor A Susceptibility gene: HLA-DR3 A Environmental Factors I. ultraviolet light food C drugs hydralazine procainamide D-penicillamine Sex hormone Infections agents

三. Pathogenic factor ▲ Susceptibility gene：HLA-DR3 ▲ Environmental Factors： a. ultraviolet light b. food c. drugs hydralazine procainamide D-penicillamine ▲ Sex hormone ▲ Infections agents

四. pathogenesis unclear

四. pathogenesis unclear

Susceptibility gene Environmental Factors/Sex hormone Helper T cell activity Hyperactivated B cell Immune complex Self antibody self antigens Multiple system involvement vasculitis

Susceptibility gene Environmental Factors Sex hormone Helper T cell activity Hyperactivated B cell Immune complex Self antibody + self antigens Multiple system involvement vasculitis

五. Pathology 1. vasculitis 2. lupus nephritis a. minimal change b. mesangial proliferative C focal segmental lesions d diffuse e, membranous f. sclerosing

五. Pathology 1. vasculitis 2. lupus nephritis a. minimal change b. mesangial proliferative c. focal segmental lesions d. diffuse e. membranous f. sclerosing

A Clinical menifestations Of sle Multiple system involvement

六.Clinical menifestations of SLE -----Multiple system involvement

1. Nonspecific symptom o fever o loss of weight o inertia

1. Nonspecific symptom ● fever ● loss of weight ● inertia

2 Skin and mucosa o skin symptoms in 80% of patients ● specIfIC features:40% malar rash discoid rash o nonspecific features 60% ● photosensitivity40% o baldness 40% o oral ulcer 60% Raynaud's phenomenon

2.Skin and mucosa ● skin symptoms in 80% of patients ● specific features: 40% malar rash discoid rash ● nonspecific features 60% ● photosensitivity 40% ● baldness 40% ● oral ulcer 60% ● Raynaud’s phenomenon