复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)丁小强-肾小球疾病 Glomerular Diseases

肾小球疾病 Glomerular diseases 丁小强 复旦大学附属中山医院
肾小球疾病 Glomerular Diseases 丁小强 复旦大学附属中山医院

a group of diseases Patho logical changes glomerular InJury clinical man i festations prote inur ia hematur ia Comp/icated causes mechanisms Various clinical manifestations Different prognosis Multiple treatment
Pathological changes -- glomerular injury Clinical manifestations --proteinuria / hematuria A group of diseases Complicated causes & mechanisms Various clinical manifestations Different prognosis Multiple treatment

primary glomerular diseases secondary glomerular diseases hereditary glomerular diseases
• primary glomerular diseases • secondary glomerular diseases • hereditary glomerular diseases

Immune mechanisms Non-immune Humoral Cell-mediated mechanisms Inflammation Glomerular diseases
Immune mechanisms Humoral Cell-mediated Non-immune mechanisms Inflammation Glomerular diseases

A Immune mechanisms (A)deposits of Circulating Immuno-Complex (CIC) circlation antigen+ antibody CIC kidney CIC/deposits
A. Immune mechanisms (A)deposits of Circulating Immuno-Complex (CIC) circilation antigen+ antibody CIC kidney CIC/deposits

antigen extrinsic drugs--nonhomologous serum penicillin foods--xenogenic protein pathogen-specific serotypes streptococci, HBV. HCV intrinsic nucleuS (SLE) cytoplasm (ANCA) cellular membrane antigen of tumor antigen of thyroid
antigen extrinsic drugs--nonhomologous serum, penicillin foods—xenogenic protein pathogen—specific serotypes streptococci, HBV, HCV intrinsic nucleus(SLE) cytoplasm(ANCA) cellular membrane antigen of tumor antigen of thyroid

Why does cic deposit in the glomeruli? Large area of glomerular capillaries more chances to contact Net structure of CIC easy to deposit and settle down Clearance dysfunction of mesangial cells. disability of mononuclear macrophage, component or function defect of complements Decrease clearance of cic
Why does CIC deposit in the glomeruli? • Large area of glomerrular capillaries --more chances to contact • Net structure of CIC --easy to deposit and settle down • Clearance dysfunction of mesangial cells, disability of mononuclear macrophage, component or function defect of complements Decrease clearance of CIC

(B)in situ Immunocomplex 1. Native renal antigen glomerular basement membrane anti-glomerular basement membrane antibod (anti-glomerular basement membrane glomerulonephritis) 2. Antigens trapped or planted DNA+ anti-DNA antibody LUpus Nephritis)
(B)in situ Immunocomplex 1. Native renal antigen glomerular basement membrane + anti- glomerular basement membrane antibody (anti- glomerular basement membrane glomerulonephritis) 2. Antigens trapped or planted DNA+ anti-DNA antibody (Lupus Nephritis)

Balance between the deposit and clearance of ic determines the situation of the diseases Persistence of antigen Clearance dysfunction of mesangial cells disability of mononuclear macrophage component or function defect of complements IC deposit clearance
Balance between the deposit and clearance of IC determines the situation of the diseases • Persistence of antigen • Clearance dysfunction of mesangial cells • disability of mononuclear macrophage • component or function defect of complements IC deposit > clearance

B. Cell-mediated immune mechanisms minimal change glomerulopathy
B. Cell-mediated immune mechanisms minimal change glomerulopathy ?
按次数下载不扣除下载券;
注册用户24小时内重复下载只扣除一次;
顺序:VIP每日次数-->可用次数-->下载券;
- 临床医学专业:《内科学》_内科学(七年制)大纲2006(上).doc
- 临床医学专业:《内科学》_内分泌和代谢系统.doc
- 临床医学专业:《内科学》_泌尿系统疾病.doc
- 临床医学专业:《内科学》_吕玲-有机磷农药中毒教案.doc
- 复旦大学:《内科学》课程教学资源(PPT课件讲稿)吕玲-有机磷农药中毒.ppt
- 临床医学专业:《内科学》_吕玲-多发性肌炎及皮肌炎教案.doc
- 复旦大学:《内科学》课程教学资源(PPT课件讲稿)吕玲-多发性肌炎及皮肌炎.ppt
- 复旦大学:《内科学》课程教学资源(PPT课件讲稿)陆福明-尿毒症.ppt
- 复旦大学:《内科学》课程教学资源(PPT课件讲稿)刘厚钰-消化总论.ppt
- 临床医学专业:《内科学》_刘厚钰-消化系统总论.doc
- 临床医学专业:《内科学》_理化系统和危重病.doc
- 临床医学专业:《内科学》_李勇-高血压教案.doc
- 复旦大学:《内科学》课程教学资源(PPT课件讲稿)李勇-高血压.ppt
- 临床医学专业:《内科学》_李益明-甲减教案.doc
- 复旦大学:《内科学》课程教学资源(PPT课件讲稿)李益明-甲减.ppt
- 临床医学专业:《内科学》_课程简介.doc
- 临床医学专业:《内科学》_教学方法.doc
- 临床医学专业:《内科学》_教材及参考书.doc
- 复旦大学:《内科学》课程教学资源(PPT课件讲稿)姜林娣-类风关.ppt
- 临床医学专业:《内科学》_姜林娣-类风关.doc
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)严萍萍-主动脉瓣狭窄 aortic stenosis.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)严萍萍-心脏瓣膜病 valvular heart disease.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)于明香 - 甲亢 Hyperthyroidism.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)何礼贤-呼吸系统总论 Disease of Respiratory System Introduction.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)刘厚钰-消化总论 Digestive System.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)吕玲-多发性肌炎及皮肌炎.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)吕玲-有机磷农药中毒 ORGANOPHORUS PESTICIDES POISONING.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)周京敏-心包疾病.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)周京敏-感染性心内膜炎 Infective Endocarditis.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)姚晨玲-急性一氧化碳中毒 Toxicity, Carbon Monoxide.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)姚晨玲-镇静催眠药中毒 Toxicity, Sedative?Hypnotics.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)姜林娣-类风关 RHEUMATOID ARTHRITIS(RA).ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)张斯为-肺心病 Chronic Pulmonary heart disease.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)张新-支气管肺癌.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)张顺财 - 黄疸鉴别 Differencial Diagnosis of Jaundice.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)徐三荣-急性胰腺炎 ACUTE PANCREATITIS.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)徐建民-出血性疾病 DISORDERS OF HEMOSTASIS.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)徐建民-特发性血小板减少性紫癜 DISORDERS OF HEMOSTASIS.ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)於强 - Systemic Lupus Erythematosus(SLE).ppt
- 复旦大学附属中山医院:《内科学》课程教学资源(PPT讲稿)於强-血管炎病的诊断与治疗 Vasculitides.ppt