复旦大学附属中山医院：《内科学》课程教学资源（PPT讲稿）邹善华 - 淋巴瘤 Lymphoma

ymphoma Zhongshan Hospital, Fudan University Zou shanhua

Lymphoma Zhongshan Hospital ,Fudan University Zou Shanhua

General considerations Definition: A group of neoplastic diseases of lymphoid tissues Classification Hodgkin′ s Disease,HD ( Hodgkin′ s Lymphoma) Non Hodgkin / s Lymphoma, NHL

Definition：A group of neoplastic diseases of lymphoid tissues Classification： Hodgkin′s Disease, HD (Hodgkin′s Lymphoma) Non Hodgkin ′s Lymphoma,NHL) General considerations

General Considerations Clinical Features ainless, progressive lymphadenectasis Fever wasting, night seat; cachexia Splenohepatomegalia E epidemiology: Incidence: urban /rural male/female; age HD8~11%;NHL90%

Clinical Features： Painless,progressive lymphadenectasis Fever,wasting,night seat；cachexia Splenohepatomegalia Epidemiology： Incidence： urban / rural;male/female;age HD 8～11％；NHL 90% General Considerations

Etiology and Pathogenesis Ⅴ irulogy: EB virus→ Burkitt lymphoma、HD HTLV-I→→ATL HTLV-II-Mycosis fungoides

Virulogy: EB virus→Burkitt lymphoma、HD HTLV-Ⅰ→ATL HTLV-Ⅱ→Mycosis fungoides Etiology and Pathogenesis

Etiology and Pathogenesis Immune states of host Immune deficiency/immune suppression Mechanism: Antigenic stimulction-y lymphadenosis(modulation t infinite proliferation → ymphoma

Immune States of Host： Immune deficiency/immune suppression Mechanism：Antigenic stimulction → lymphadenosis(modulation↓ ) → infinite proliferation →lymphoma Etiology and Pathogenesis

Classification of Lymphoma HD: Reed-Sternberg(r-s) cell Rye Classification, 1966 Lymp hocyte predominance Nodular sclerosis Mixed cellularity Lymphocyte depletion

HD：Reed-Sternberg(R-S) Cell Rye Classification ，1966 Lymphocyte predominance Nodular sclerosis Mixed cellularity Lymphocyte depletion Classification of Lymphoma

Classification of Lymphoma NHLa IWF,1982 REAL, 1994 wHO,2000

NHL： IWF，1982 REAL，1994 WHO，2000 Classification of Lymphoma

Working formulation Low-grade lymphoma A small lymphocytic, consistent with chronic lymphocytic leukemia plasmacytoid B follicular, predominantly small cleaved cell diffuse areas sclerosis C follicular, mixed small cleaved and large cell diffuse areas sclerosis

Working formulation Low-grade lymphoma A. small lymphocytic, consistent with chronic lymphocytic leukemia plasmacytoid B. follicular, predominantly small cleaved cell diffuse areas sclerosis C. follicular, mixed small cleaved and large cell diffuse areas sclerosis

Working formulation Intermediate-grad lymphoma D. follicular, predominantly large cell diffuse areas sclerosis E diffuse small cleaved cell sclerosis F diffuse, mixed small and large cell sclerosis epithelioid cell com ponent G. diffuse, large cell cleaved cell noncleaved cell sclerosis

Working formulation Intermediate-grad lymphoma D. follicular, predominantly large cell diffuse areas sclerosis E. diffuse, small cleaved cell sclerosis F. diffuse, mixed small and large cell sclerosis epithelioid cell component G. diffuse, large cell cleaved cell noncleaved cell sclerosis

Working formulation High-grade lymphoma H. mmunoblastic, large cell plasmacytoid clear cell polymorphous epithelioid cell component lymphoblastic, convoluted or nonconvoluted cell 3. small noncleaved cell. burkitt's or non-Burkitt's

Working formulation High-grade lymphoma H. mmunoblastic, large cell plasmacytoid clear cell polymorphous epithelioid cell component I. lymphoblastic, convoluted or nonconvoluted cell J. small noncleaved cell, Burkitt's or non-Burkitt's