中国医科大学：《病理学》课程教学课件（PPT讲稿，英文）Chapter 15 Infectious disease1

Chapter 15Infectiousdisease

Infectious disease Chapter 15

S1IntroductionAlthough the features ofpathologic change of infectiousdiseases is different, its basicpathological changes is thesame, belong to the inflammation

§1 Introduction Although the features of pathologic change of infectious diseases is different, its basic pathological changes is the same, belong to the inflammation

InfectionInfluenzaDiphtheriaShigella dysenterySkin,throat,Ascendingpyelonephritislung,intestine,urinarytractLymphnodeDengueMalariaLymphaticTyphusBloodstreamBrainLiverSalivaryglandLungsKidneySkinPoliomyelitisHepatitisBYellowfeverMumpsRabiesChickenpoxHematogenousMeaslesYawspyelonephritisRubella

Acute:Fibrinous→bacillary dysentery;Suppurative-→suppurativemeningitisChronic:Granulomatouss inflammationTB,leprosy

◆ Acute: Fibrinous→bacillary dysentery; Suppurative→suppurative meningitis ◆ Chronic: Granulomatous inflammation TB, leprosy

S2Tuberculosis(一)Outline1. Concept:TB is a chronic granulomatousdisease caused by tubercle bacilliThe lung is his prime target, but anyorgan may be infected

§2 Tuberculosis (一) Outline 1. Concept: TB is a chronic granulomatous disease caused by tubercle bacilli The lung is his prime target, but any organ may be infected

The characteristic lesion Formation of tubercleCentral caseous necrosis

The characteristic lesion : ▪ Formation of tubercle ▪ Central caseous necrosis

2. ClassificationTBPulmonaryprimary TBsecondaryTBExtra pulmonary TBCintestinal TBtuberculous meningitistuberculous peritonitisTB of bone,jointTB ofLNTB ofurinary SgenitalS

2. Classification Pulmonary TB primary TB secondary TB Extra pulmonary TB intestinal TB tuberculous meningitis tuberculous peritonitis TB of bone , joint TB of LN TB of urinary S genital S

二. Etiology and Pathogenesis1. The pathogenic organismG+Mycobacterium TBTuberclebacillus(1) Type:M. hominidmainlyresponsibleforM.bovinedisease in manMouse, fish type-→have no virulence in host

二. Etiology and Pathogenesis 1. The pathogenic organism Mycobacterium TB G+ Tubercle bacillus (1) Type: M. hominid M. bovine Mouse, fish type→have no virulence in host mainly responsible for disease in man

Routesofinfection(2) Respiratory tract: maindirect personntopersontransmission of sneeze,cough droplets withorganisms(1-20 bacteria droplet)

(2) Routes of infection ① Respiratory tract: main direct person to person transmission of sneeze, cough droplets with organisms(1-20 bacteria / droplet)