中国医科大学：《病理学》课程教学课件（PPT讲稿，英文）Chapter 11 Diseases of urinary system（1/2）

11ChapterofDiseasesurinarysystem

Chapter 11 Diseases of urinary system

Int roduction

Functions of kidney(一)1.Excretes the wasteproducts of metabolism2. Precisely regulates the body'sconcentration ofwaterand salt3.Maintains the appropriate acid-alkalinebalanceofplasma4.Serves as an endocrine organ:erythropoietinreninprostaglandin

(一) Functions of kidney 1. Excretes the waste products of metabolism 2. Precisely regulates the body’s concentration of water and salt 3. Maintainsthe appropriate acid￾alkaline balance of plasma 4. Serves as an endocrine organ: erythropoietin renin prostaglandin

(二) RenalstructureCapillary tuftGlomerulusRenal capsule(Bowman's capsule)NephronProximal tubuleThin segmentRenal tubuleDistal tubuleCollecting duct

(二) Renal structure Nephron Collecting duct Glomerulus Renal tubule Capillary tuft Renal capsule (Bowman’s capsule) Proximal tubule Thin segment Distal tubule

Renalstructure△proximal tubuledistal tubule△

Renal structure proximal tubule distal tubule

GLOMERULUSCapillaryUrinaryspaceloopsMesangiumMesangial cellMesangial matrixRed cellParietal epitheliumFenestrae inProximalendotheliumtubuleUrinary spaceCapillarylumenParietalepitheliumBasementmembraneVisceralepitheliumFootprocessesEndotheliumBasementmembraneRed cellBFootprocesses

Renalstructure

Renal structure

RenalstructureCLCI

Renal structure

1. Filteringmembrane· Endothelial cells (EC). Glomerular basement(GBM)membrane Visceral epithelial cell(podocyte）

1. Filtering membrane • Endothelial cells (EC) • Glomerular basement membrane (GBM) • Visceral epithelial cell ( podocyte )

FilteringmembraneRCaEpREp

Filtering membrane