《生物化学》课程教学资源（PPT课件讲稿）第三章 维生素 vitamin

Chapter 3. vitamin Lipid-soluble vitamin Water-soluble vitamin

Chapter 3. vitamin Lipid-soluble vitamin Water- soluble vitamin

论述题 (查资料课外完成) ◇试述维生素A缺乏射,为什么会患夜盲症?

◆试述维生素A缺乏时，为什么会患夜盲症？ 论述题 （查资料课外完成）

introduction Vitamins are organic nutrients that are required in small quantities for a variety of biochemical functions and which, generally, cannot be synthesized by the body and must therefore be supplied by the diet Lipid-soluble vitamin vitamin Water-soluble vitamin

introduction Vitamins are organic nutrients that are required in small quantities for a variety of biochemical functions and which, generally, cannot be synthesized by the body and must therefore be supplied by the diet. Lipid-soluble vitamin Water-soluble vitamin vitamin

Section 1. lipid-soluble vitamin Vitamin A, D, E and K are soluble in lipids, not in water They lay with lipids in food and therefore absorbed together with lipids by body

Section 1. lipid-soluble vitamin Vitamin A, D, E and K are soluble in lipids, not in water. They lay with lipids in food and therefore absorbed together with lipids by body

I Vitamin a CHOH CH,OH A Vitamin a1, retino,视黄醇 Vitamin a2, dehydroretinol,脱氡视黄醇

Ⅰ. Vitamin A Vitamin A1, retinol, 视黄醇 Vitamin A2, dehydroretinol, 脱氢视黄醇

CH oxidation of aldehyde Retinoic acid Hormonal to acid (d) sign thelial CH. CH CH. CH3 CHs CHs CH CH visible CH ight CHa -CH Neuronal point of OXI ono sIgna cleavage 11 alcohol to 11 Dehyde 11 to brain CHs CH3 H Vitamin A1 11-cis-Retinal (retinol) (visual pigment all-trans-Retinal CH (b) (e) CH B-Carotenc

Function: wm keep epithelial tissue healthy. 米 Maintaining orthosia(正常视觉) Deficiency diseases night-blindness夜盲症 Source β- carotinβ—胡萝卜素(7.7mg/100g)

Function: keep epithelial tissue healthy. Maintaining orthopsia(正常视觉). Source: β – carotin β—胡萝卜素 (7.7mg/100g) Deficiency diseases: night-blindness 夜盲症

∏. Vitamin d R HO 麦角固醇 维生素D2 7-脱氢胆固醇 维生素D3 22-双氢麦角固醇 维生素D4 7-脱氢谷固醇 维生素D5 Among them, 1, 25-dihydroxycholecalciferol is the biological most active

Ⅱ．Vitamin D HO R 麦角固醇 7-脱氢胆固醇 22-双氢麦角固醇 7-脱氢谷固醇 维生素D2 维生素D3 维生素D4 维生素D5 Among them, 1,25-dihydroxycholecalciferol is the biological most active

HaC CH3 HoC CH3 HO 3 7-Deh UV light 2 steps (in skin) Ha CHa HC CH. Cholecalciferol (vitamin D3) HO 1 step in the liver 1 step in the kidney H3C CH3 Hoc CH2 1, 25-Dihydroxycholecalciferol 题 (1, 25-dihydroxyvitamin D3)

Function Promote absorbing of calcium and phosphonium into intestine, adjust calcium and phosphorus metabolism, be helpful of ossature(骨骼) calcifying and tooth forming Deficiency deseases actitis(偻病) osteomalacia(软骨病) 「A Source fish-liver o,yok蛋黄,mik

Function: Promote absorbing of calcium and phosphonium into intestine, adjust calcium and phosphorus metabolism, be helpful of ossature(骨骼)calcifying and tooth forming. Deficiency deseases: rachitis(佝偻病 )osteomalacia(软骨病) Source: fish-liver oil，yolk蛋黄，milk