复旦大学：《人体的社交网络——共生微生物》课程教学资源（文献讨论）Mode of birth Delivery Affects Oral Microbiota in Infants

Mode of birth Delivery Affects Oral Microbiota in Infants 第五组赵钎虞逸静 郝雅婧邬开宬

第五组 赵钎 虞逸静 郝雅婧 邬开宬

Introduction

Introduction

Background 01 Four Background Facts

Background 01 Four Background Facts

Fact I 02 Differences of first exposure to micro rganism between vaginally delivered infants and c-section delivered ones 01 >Vaginally delivered: birth canal >C-section delivered: skin of parents and health providers, medical equipment

01 Fact I •Differences of first exposure to micro￾organism between vaginally delivered infants and C-section delivered ones. Vaginally delivered: birth canal; C-section delivered: skin of parents and health providers, medical equipment. 02

Fact ll 03 Modes of delivery lead to differences in the intestinal microbiota in infants Vaginally delivered: higher diversity 02 >C-section delivered: higher numbers of Clostridium difficile(艰难梭菌), delayed acquisition of bifidobacteria(双歧杆菌) and escherichia coli

02 Fact II • Modes of delivery lead to differences in the intestinal microbiota in infants. Vaginally delivered: higher diversity; C-section delivered: higher numbers of Clostridium difficile(艰难梭菌), delayed acquisition of bifidobacteria(双歧杆菌) and Escherichia coli. 03

FactⅢl 05 C-section compared with vaginal delivery, may be related with a reduced natural barrier 03 Mutans streptococci(变形链球菌)were detected more frequently and at a younger age in children delivered by c-section than in those delivered vaginally

Fact III • C-section, compared with vaginal delivery, may be related with a reduced natural barrier. Mutans streptococci(变形链球菌) were detected more frequently and at a younger age in children delivered by C-section than in those delivered vaginally. 03 05

Fact v 06 Lack of information about the establishment of the microbiota in oral cavit' y 04 >We know less information about factors influencing establishment of the microbiota in the oral cavity than reported for the gut

Fact IV 0 5 • Lack of information about the establishment of the microbiota in oral cavity. We know less information about factors influencing establishment of the microbiota in the oral cavity than reported for the gut. 043 06

THE AIM To compare oral microbiota and seeking differences in colonization patterns in infants delivered vaginally or by c section Vaginally delivered C-section

To compare oral microbiota and seeking differences in colonization patterns in infants delivered vaginally or by C￾section. THE AIM Vaginally delivered C-section

Methods

Methods

Study Population 207 mothers v In northern Sweden C-section v Delivered a healthy baby selection in the previous 3 months Vaginally delivered √ Accpet the study 26 Mode of delivery ● body weight&| length Data ○ Antibiotics O Other possible confounders

Study Population Data Mode of delivery Antibiotics Body weight & length Other possible confounders 01 207 mothers In Northern Sweden Delivered a healthy baby in the previous 3 months Accpet the study selection C-section Vaginally delivered 41 26 11