复旦大学：《内科学》课程教学资源（PPT课件讲稿）General Concepts of Renal Disease

General Concepts of renal Disease 2005-3-10 Huashan hospital, Fudan University

1 General Concepts of Renal Disease 2005-3-10 Huashan hospital,Fudan University

Contents Normal anatomy, physiology and metabolism of the kidney Clinical manifestation of renal disease Diagnosis and treatment

2 Contents • Normal anatomy,physiology and metabolism of the kidney • Clinical manifestation of renal disease • Diagnosis and treatment

Anatomy of the Kidney Structure of the kidney The nephron Renal vasculature Interstitium

3 Anatomy of the Kidney • Structure of the kidney • The nephron • Renal vasculature • Interstitium

The nephron · Glomerulus Bowman's capsule Tubulus

4 The nephron • Glomerulus • Bowman’s capsule • Tubulus

The glomerulus Glomerular endothelium The podocytes · The mesangium The filtration barrier

5 The glomerulus • Glomerular endothelium • The podocytes • The mesangium • The filtration barrier

The filtration barrier The endothelium Glomerular basement membrane The podocyte foot process

6 The Filtration Barrier • The endothelium • Glomerular basement membrane • The podocyte foot process

Physiology of the Kidney Glomerular filtration Renal tubular reabsorption Kidney and endocrine system

7 Physiology of the Kidney • Glomerular filtration • Renal tubular reabsorption • Kidney and endocrine system

Clinical manifestation of renal disease Edema Hypertension Flank pain Dysuria and frequency Oliguria and anuria Polyuria and nocturia Proteinuria and hematuria

8 Clinical Manifestation of Renal Disease • Edema • Hypertension • Flank pain • Dysuria and frequency • Oligulia and anuria • Polyuria and nocturia • Proteinuria and hematuria

Clinical manifestation of renal disease Pyuria and bacilluria Renal insufficiency

9 Clinical Manifestation of Renal Disease • Pyuria and bacilluria • Renal insufficiency

Oliguria Prerenal oliguria Parenchymatous oliguria Postrenal oliguria

10 Oliguria • Prerenal oliguria • Parenchymatous oliguria • Postrenal oliguria