大连医科大学：《组织胚胎学》课程教学课件（英文讲稿）05.Blood

BLOOD9O080

BLOOD BLOOD BLOOD BLOOD

ContentsBloodPlasmaBloodcellsBloodplateletsHematopoiesis

 Plasma Contents  Blood cells  Blood  Blood platelets  Hematopoiesis

ConstructionPlasma (intercellularPlasmamatrix) : 55%Hemocytes (cells): 45%erythrocytes RBCLeucocytesleucocytes WBC&Platlets blood plateletshematocrit (packed red cellvolume): 45%Erythrocytes*using anticoagulants

Construction Construction Plasma (intercellular matrix) : 55% Hemocytes (cells)：45% erythrocytes RBC leucocytes WBC blood platelets • hematocrit (packed red cell volume): 45% Plasma Leucocytes & Platlets Erythrocytes *using anticoagulants

101010999888Plasma7I755%66Serum6555Leukocytes&44platelets333Erythrocytes2245%-Clotting211*using anticoagulants*withoutheparin*centrifugationanticoagulants

*without anticoagulants ——Serum ——Clotting *using anticoagulants heparin *centrifugation Leukocytes & platelets 55% 45%

PlasmaSerumSamecomponents90% waterwithout fibrinogen10% others :fibrinogen → fibrinplasma pr.c albuminfibrinogenenzymesserumIg.etc.PlasmalipidhormonesVitaminsbloodclotsinorganic saltsmetabolites

90% water 10% others : plasma pr. albumin fibrinogen enzymes Ig. etc. lipid hormones Vitamins inorganic salts metabolites Same components without fibrinogen serum Serum Plasma blood clots fibrinogen fibrin  Plasma

Bloodcellsbloodsmearstains withWrightorGiemsa080

blood smear blood smear stains with Wright or Giemsa stains with Wright or Giemsa  Blood cells

Erythrocytes>biconcavedisc,7.5μmno nuclei, no organelles>hemoglobin:（Hb）transporting&binding O, and CO2 carbon monoxideflaxible>bloodgroup(ABO)agglutinogen>lifespan:120dGroupAGroupBGroupABGraupoRad bloo>normalconcentrationcelltypefemale:3.9-5.5X106/uL祥恭茶Artibodlkmale:4.1-6X10%/μLpresemtAnd-BAn-ANeneAnd-andAnAntigenaAaridEAantigenBantigenpresentNoneartleens

 biconcave disc, 7.5μm no nuclei，no organelles  hemoglobin: （Hb）transporting & binding O2 and CO2 carbon monoxide flaxible  blood group (ABO) agglutinogen  life span: 120 d  normal concentration female: 3.9-5.5×106/μL male: 4.1-6×106/μL Erythrocytes

MedicalApplication>Anemia: R.B.CErythrocytosis:anisocytosis>macrocytes>9μm; microcytes hereditary spherocytosis: defects inspectrin molecule;easytobedestructed by macrophages

Medical Application  Anemia ：R.B.C 9 μm; microcytes < 6 μm; anisocytosis  Sickle cell disease: caused by a mutation of one nucleotide. the triplet GAA for glutamic acid is changed to GUA for valine  hereditary spherocytosis: defects in spectrin molecule; easy to be destructed by macrophages

ReticulocytesimmatureRBC,justreleasedfrombonemarrow1% of the total number of erythrocytes3-6%in newbornresidual ribosome--- netlike structure(brilliant cresyl blue)Increase in anemia indicator ofhematopoietic capacityofthebonemarrow

Reticulocytes  immature RBC, just released from bone marrow  1% of the total number of erythrocytes, 3-6% in newborn  residual ribosome- netlike structure (brilliant cresyl blue)  Increase in anemia indicator of hematopoietic capacity of the bone marrow

LeukocytesSpherical,nucleate&colorless,6000---10.000/uLClassification:based on specific granules andnonspecificlazurophilic granulesneutrophil: 60 ~ 70%eosinophil: 2 ~ 4%Granulocyte65-70%basophil: 0.5%lymphocyte:28%Agranulocytemonocyte: 5%30-35%

 Spherical, nucleate & colorless, 6000-10,000/μL  Classification: based on specific granules and nonspecific/azurophilic granules Granulocyte Agranulocyte neutrophil：60～70% eosinophil：2～4% basophil：0.5% lymphocyte：28% 30-35% monocyte：5% 65-70% Leukocytes