复旦大学：《耳鼻咽喉科学》课程教学资源（PPT课件讲稿，英文版）Nasophar-CA-980121

Nasopharyngeal Angiofibroma: Juvenile Nasopharyngeal Angiofibroma (UNA highly vascular benign yet unencapsulated tumor of adolescent maes

Nasopharyngeal Angiofibroma: Juvenile Nasopharyngeal Angiofibroma (JNA) highly vascular benign yet unencapsulated tumor of adolescent males

Frequency: JNA accounts for 0. 05%o of all head and neck tumors Sex: JNA occurs exclusively in males Age: range is 7-19 years. JNA iS rare in patients older than 25 years Etiology: A hormonal theory has been suggested due to the lesion's occurrence in adolescent males

Frequency: JNA accounts for 0.05% of all head and neck tumors. Sex: JNA occurs exclusively in males. Age: range is 7-19 years. JNA is rare in patients older than 25 years Etiology: A hormonal theory has been suggested due to the lesion's occurrence in adolescent males

Pathophysiology The tumor starts adiacent to the a sphenopalatine foramen. Large tumors frequently are bilobed or dumbbell-shaped with one portion of the tumor filling the nasopharynx and the other portion extending to the pterygopalatine fossa

Pathophysiology: The tumor starts adjacent to the sphenopalatine foramen. Large tumors frequently are bilobed or dumbbell-shaped, with one portion of the tumor filling the nasopharynx and the other portion extending to the pterygopalatine fossa

Clinical: Symptoms Nasal obstruction (80-90%0) Epistaxis(45-60%0) Headache(25%) Facial swelling(10-18%0 Other symptoms include unilateral rhinorrhea, anosmia, hyposmia, rhinolalia deafness, otalgia, swelling of the palate, and deformity of the cheek

Clinical: Symptoms: Nasal obstruction (80-90%): Epistaxis (45-60%): Headache (25%): Facial swelling (10-18%) Other symptoms include unilateral rhinorrhea, anosmia, hyposmia, rhinolalia, deafness, otalgia, swelling of the palate, and deformity of the cheek

Igns Nasal mass(80%) Orbital mass(15%) 3 Proptosis (10-15%) Other signs may include Serous otitis due to eustachian tube blockage - zygomatic swelling and trismus denote spread of the tumor to the infratemporal fossa

Signs: Nasal mass (80%) Orbital mass (15%) Proptosis (10-15%) Other signs may include -Serous otitis due to eustachian tube blockage. -Zygomatic swelling and trismus denote spread of the tumor to the infratemporal fossa

Differentials: Other causes of nasal obstruction,(eg, nasal polyps, antrochoanal polyp, teratoma, encephalocele, dermoids, inverting papilloma, rhabdomyosarcoma, squamous cell carcinoma) Other causes of epistaxis, systemic or local Other causes of proptosis or orbital swelling

Differentials: Other causes of nasal obstruction, (eg, nasal polyps, antrochoanal polyp, teratoma, encephalocele, dermoids, inverting papilloma, rhabdomyosarcoma, squamous cell carcinoma) Other causes of epistaxis, systemic or local Other causes of proptosis or orbital swelling

CT scan

CT scan

Medical therapy: Surgical therapy Hormonal therapy Radiotherapy Biopsy is prohibited because of severe bleeding

Medical therapy: Surgical therapy Hormonal therapy Radiotherapy Biopsy is prohibited because of severe bleeding

Nasopharyngeal malignancies t- Nasopharyngeal carcinoma(NPC) Lymphoma Salivary gland tumors Sarcomas

Nasopharyngeal malignancies – Nasopharyngeal carcinoma (NPC) – Lymphoma – Salivary gland tumors – Sarcomas