《为大学化学做准备-》 英文版 化学

to Letsttbgkdieansietry Luis avila avilaachem columbia edu Room. chandler 455 Phone#:(212)854-8587

1 Luis Avila avila@chem.columbia.edu Room: Chandler 455 Phone #: (212)854-8587

WhyhavAs CKehetsistoDo? "Take white lead, one part, and any glass substnupcible and then pour the mixture. To Mm3签1?是 ss and after forty days you will find emeralds Utilizes natural substances and creates artificial ones. ConpnelkandsMlhtlooyya atlcaenigtinEdiyngodegaatemastry Dover: New York 1960, p. 160 Provides a molecular interpretation ofhealth and disease

2 What Does a Chemist Do? What is Chemistry? • Studies the atomic composition and structural features of substances. • Investigates the varied interactions among substances • Utilizes natural substances and creates artificial ones. • Comprehends the complex chemistry of living organisms. • Provides a molecular interpretation of health and disease. “Take white lead, one part, and any glass you choose, two parts, fuse together in a crucible and then pour the mixture. To this crystal add the urine of an ass and after forty days you will find emeralds” Stillman, J. M. The story of Alchemy and Early Modern Chemistry; Dover: New York 1960, p. 160

How Does shehe do it? Main Divisions of chemistry Organic Chemistry Inorganic Chemistry Materials Chemistry Physical Chemistry Analytical Chemistry Environmental Chemistry Industrial Chemistry Chemical engineering and Applied chemistry) Forensic Chemistry Biochemistry

3 Main Divisions of Chemistry Organic Chemistry Inorganic Chemistry Physical Chemistry Analytical Chemistry Industrial Chemistry (Chemical Engineering and Applied Chemistry) Biochemistry How Does She/He do it? Materials Chemistry Environmental Chemistry Forensic Chemistry

What is Organic chemistry? Largest area of specialization among the various fields of chemistr Synthetic Organic Chemistry Pharmaceutical chemistr Polymer chemistry Dye and Textile chemistry Pulp and Paper chemistry Agricultural Chemistry ormulation Chemistry(paint, food, petroleumproducts, adhesives, etc. Physical Organic Chemistry Correlates the physical and chemical properties of compounds with their structural features

4 What is Organic Chemistry? Physical Organic Chemistry Largest area of specialization among the various fields of chemistry Synthetic Organic Chemistry • Pharmaceutical Chemistry • Pulp and Paper Chemistry • Dye and Textile Chemistry • Formulation Chemistry (paint, food, petroleum products, adhesives, etc.) • Agricultural Chemistry • Polymer Chemistry Correlates the physical and chemical properties of compounds with their structural features

We are interested in the multistep synthesis of natural products, as well as the development ofnew methodology, particularly to address problems of regio- or stereocontroL At present(1999), we are working on problems suggested by structures such as those of germine, taxol cardenolides and codeine Synthetic Organic chemist Professor Gilbert stork

5 We are interested in the multistep synthesis of natural products, as well as the development of new methodology, particularly to address problems of regio- or stereocontrol. At present (1999), we are working on problems suggested by structures such as those of germine, taxol, cardenolides and codeine Synthetic Organic Chemist: Professor Gilbert Stork

2-acetylnerifolin( class Cardenolide) Natural Product with Antitumor Activity 无法显示该图片 冈无法显示该图片 Tarol Natural Product with Antitumor Activity

6 2-acetylnerifolin (class Cardenolide) Natural Product with Antitumor Activity Taxol Natural Product with Antitumor Activity

Among our areas of current interest in the anticancer field are epothilone and eleutherobin. While structurally diverse, these two compounds seem to function by a taucol-like mechanism in their ability to inhibit microtubule disassembly. Several projects are addressed to goal systems with immunochemical implications. Here we are Synthetic Organic chemist/ particularly concerned with the Bioorganic chemist: construction of a carbohydrate Professor Samuel danishefsky based tumor antigen vaccine

7 Among our areas of current interest in the anticancer field are epothilone and eleutherobin. While structurally diverse, these two compounds seem to function by a taxol-like mechanism in their ability to inhibit microtubule disassembly. Several projects are addressed to goal systems with immunochemical implications. Here we are particularly concerned with the construction of a carbohydrate￾based tumor antigen vaccine. Synthetic Organic Chemist / Bioorganic Chemist: Professor Samuel Danishefsky

We deal with structural aspects of bioactive compounds and elucidation of their mode of action. In most cases this involves investigating the interaction of small molecules with their biopolymeric receptors. The recent dramatic advancement in isolation, purification and microspectroscopic methods has made it possible for chemists to become involved in such studies on a molecular structural basis Natural Products chemist Professor Koji nakanishi

8 In most cases this involves investigating the interaction of small molecules with their biopolymeric receptors. The recent dramatic advancement in isolation, purification and microspectroscopic methods has made it possible for chemists to become involved in such studies on a molecular structural basis Natural Products Chemist : Professor Koji Nakanishi We deal with structural aspects of bioactive compounds and elucidation of their mode of action

We view the photon as a reagent for initiating photoreactions and as a product of the deactivation of electronically excited molecules Our group is developing a novel field termed supramolecular photochemistry, or photochemistry beyond the conventional intellectual and scientific constraints implied by the term molecule. In supramolecular processes non-covalent bonds between molecules play a role analogous to that of covalent bonds between atoms Physical organic Chemist/Photochemist Material chemist Professor Nicholas turro

9 We view the photon as a reagent for initiating photoreactions and as a product of the deactivation of electronically excited molecules. Physical Organic Chemist / Photochemist Material Chemist: Professor Nicholas Turro Our group is developing a novel field termed "supramolecular" photochemistry, or photochemistry beyond the conventional intellectual and scientific constraints implied by the term "molecule". In supramolecular processes non-covalent bonds between molecules play a role analogous to that of covalent bonds between atoms

What is Inorganic Chemistry? Deals with the properties ofelements ranging from metals to non metals Organometallic Chemistry Bioinorganic chemistry Ceramics and glass Semiconductors

10 What is Inorganic Chemistry? Deals with the properties of elements ranging from metals to non metals • Organometallic Chemistry • Bioinorganic Chemistry • Ceramics and Glass • Semiconductors