复旦大学：《传染病学 Infectious Disease》课程教学资源（MBBS）教学课件（英文）血吸虫病 Schistosomiasis

Schistosomiasis Li Qian Department of InfectioUs Diseases, Huashan Hospital, Fudan University

Schistosomiasis Li Qian Department of Infectious Diseases, Huashan Hospital, Fudan University

Topics Definition The Pathogen Epidemiology Etiology and Life cycle Pathobiology Clinical manifestations Diagnosis Treatment

2 Topics  Definition  The Pathogen  Epidemiology  Etiology and Life Cycle  Pathobiology  Clinical manifestations  Diagnosis  Treatment

DEFINITION Schistosomiasis is one of the most Important parasitic diseases of humans and is a global public health problem in the developing world

3 DEFINITION  Schistosomiasis is one of the most important parasitic diseases of humans and is a global public health problem in the developing world

DEFINITION The disease is caused by trematodes of the genus Schistosoma, which cause periportal fibrosis and liver cirrhosis owing to deposition of eggs in the small portal venules Schistosoma mansoni and schistosoma Japonicum lead to liver disease

4 DEFINITION  The disease is caused by trematodes of the genus Schistosoma, which cause periportal fibrosis and liver cirrhosis owing to deposition of eggs in the small portal venules.  Schistosoma mansoni and Schistosoma japonicum lead to liver disease

History Schistosomiasis is known as bilharzia or bilharziosis in many countries, after German physician Theodor Bilharz, who first described the cause of urinary schistosomiasis in 1851 The first doctor who described the entire disease cycle was Praja da silva in 1908 It was a common cause of death for Ancient Egyptians in the greco-roman period

5 History  Schistosomiasis is known as bilharzia or bilharziosis in many countries, after German physician Theodor Bilharz, who first described the cause of urinary schistosomiasis in 1851.  The first doctor who described the entire disease cycle was Pirajá da Silva in 1908.  It was a common cause of death for Ancient Egyptians in the Greco-Roman Period

The Pathogen Five major species of Schistosoma affect humans: s. mansonis haematobium. s japonicum, S intercalatum, and s. mekongi Other Schistosoma species that occasionally infect humans include s bovis .S. mattheei and some avian schistosomes

The Pathogen  Five major species of Schistosoma affect humans: S. mansoni, S. haematobium, S. japonicum, S. intercalatum, and S. mekongi.  Other Schistosoma species that occasionally infect humans include S. bovis, S. mattheei, and some avian schistosomes

The Pathogen These species differ biologically from one another and in their geographic distribution and the type of disease that they produce The schistosomes are digenetic parasitic trematodes. Although they are morphologically distinct, the species of Schistosoma that infect humans share some common factors

7 The Pathogen  These species differ biologically from one another and in their geographic distribution and the type of disease that they produce.  The schistosomes are digenetic parasitic trematodes. Although they are morphologically distinct, the species of Schistosoma that infect humans share some common factors

The Pathogen The large male(0.6 to 2cm×2to4mm) has a ventral gynecophoric canal in which the female(1.2 to2.6cm×lto2 mm)is held during copulation

8 The Pathogen  The large male (0.6 to 2.2 cm × 2 to 4 mm) has a ventral gynecophoric canal in which the female (1.2 to 2.6 cm × 1 to 2 mm) is held during copulation

EPIDEMIOLOGY Schistosomiasis occurs mainly in rural agricultural and periurban areas Infection with S. mansoni is found in parts of south America. Africa and the middle east Infection with S japonicum is found in the Far east mostly China and the philippines In China, 0. 67% of the population may be infected according to cdc statistical report at 2008

9 EPIDEMIOLOGY  Schistosomiasis occurs mainly in rural agricultural and periurban areas.  Infection with S. mansoni is found in parts of South America, Africa, and the Middle East.  Infection with S. japonicum is found in the Far East, mostly China and the Philippines.  In China, 0.67% of the population may be infected, according to CDC statistical report at 2008. 

EPIDEMIOLOGY Infection sources Mode of transmission Susceptible population

10 EPIDEMIOLOGY  Infection sources  Mode of transmission  Susceptible population