山东大学：《药剂学 Pharmaceutics》课程教学资源（PPT课件讲稿，双语）10 Transdermal Drug Delivery Systems 经皮给药系统

10. Transdermal Drug Delivery Systems 经皮给药系统

10. Transdermal Drug Delivery Systems 经皮给药系统

Contents Factors affecting percutaneous absorption Percutaneous absorption enhancer IIL. Design features of transdermal drug delivery system I. Percutaneous absorption model Advantages and disadvantages of TDDSs VI. Examples of transdermal drug deliver systems VIl. General clinical considerations in the use of TDDSs

Contents I. Factors affecting percutaneous absorption II. Percutaneous absorption enhancer III. Design features of transdermal drug delivery system IV. Percutaneous absorption model V. Advantages and disadvantages of TDDSs VI. Examples of transdermal drug deliver systems VII. General clinical considerations in the use of TDDSs

a Transdermal drug delivery systems(TDDSs) facilitate CoVER the passage of therapeutic MAGNET MEDICINE quantities of dr ru g ADHESSIVE substances through the skin and into the general circulation for their systemic effect 经皮给药系统能促进具治 疗量的药物透过皮肤,进 入体循环发挥系统作用

◼ Transdermal drug delivery systems (TDDSs) facilitate the passage of therapeutic quantities of drug substances through the skin and into the general circulation for their systemic effect. ◼ 经皮给药系统能促进具治 疗量的药物透过皮肤，进 入体循环发挥系统作用

For transdermal drug delivery, it is considered ideal if the drug penetrates through the skin to the underlying blood supply 智早 without drug buildup in the dermal layers 理想的经皮给药系统时,药物 渗透入皮肤后,能够进入血液 而不在皮下蓄积。 (3M Transdermal Drug Delivery http://www.3m.com/dds)

◼ For transdermal drug delivery, it is considered ideal if the drug penetrates through the skin to the underlying blood supply without drug buildup in the dermal layers. ◼ 理想的经皮给药系统时，药物 渗透入皮肤后，能够进入血液 而不在皮下蓄积。 (3M Transdermal Drug Delivery http://www.3M.com/DDS)

hair shaft- Subcutaneous Epidermis Intramuscular sensory(ii Transdermal Dermis nerre Subcutanious rein arery hair folicle

transcellular intercellular follicular eccrine

Stratum corneum Living dermis Dermal vasculature Eccrine gland duct

Macroflux③ hGH-Coated Microprojections

Macroflux®

E-TRANSQ 69

E-TRANS®

Benefits of TDDSs Eliminates potential pain associated with injections No first pass metabolism in liver Eliminates gastrointestinal side effect a Improves patient compliance due to simpler, pain free delivery Potential for home administration

Benefits of TDDSs ◼ Eliminates potential pain associated with injections ◼ No first pass metabolism in liver ◼ Eliminates gastrointestinal side effect ◼ Improves patient compliance due to simpler, pain free delivery ◼ Potential for home administration