河北医科大学：《天然药物化学》课程教学资源（课件讲稿）天然药物化学的魅力 4/13

Piperidine Alkaloids Steroids-Keys to Life 体物的究在制工业史中空来者的原大最桌中的新究 Big Figures in Steroid Chemistry 所有明星药物之母 避孕药 5万头蒲的卵巢中只能提取出20me的孕聊 (N Father of the Pill ‘Marker Degradation's c2c be e

1 Piperidine Alkaloids Senecio madagascariensis (Fireweed) May 2008, 190 people were affected and 17 had died from liver failure in Afghanistan. camel belly 骆驼肚子 千里光—吡咯啶 异炔诺酮 Steroids—Keys to Life Adolf O. R. Windaus Adolf F. J. Butenandt Leopold Ružička Sir John W. Cornforth Tadeus Reichstein Philip Showalter Hench 幸福药 甾体药物的研究在制药工业史中空前未有的最大最集中的研究 George Rosenkranz Carl Djerassi (1923-2015) Percy Lavon Julian “Soy bean chemist” (1899- 1975) Russell Marker Big Figures in Steroid Chemistry 5万头猪的卵巢中只能提取出20 mg的孕酮 张民觉 所有明星药物之母——避孕药 Gregory Goodwin Pincus 玛格丽特·桑格（Margaret Sanger) 凯瑟琳Katherine McCormick John Rock 格雷戈里·平卡斯 54年Lasker Award获得者 1908-1991 Carl Djerassi (1923 –2015) was a Bulgarian, Austrian and American chemist, Novelist, and Playwright best known for his contribution to the development of oral contraceptive pills. He also elucidated the structure of steroids, an area in which he published over 1,000 papers。 Father of the Pill Luis E. Miramontes 杰拉西 （翟若适）斯坦福大学 1978 沃尔夫化学奖 William Summer Johnson (1913 –1995) ‘Marker Degradation’ Russell Marker and Carl Djerassi A total synthesis of progesterone was reported in 1971 by Johnson Pennsylvania State College 1939年 H O + O O O O P(C6H5)3 O O O O OH O O H H H progesterone

来自覆生德的陵 ol-jx 神奇药物应该提早10年同世？ 2

2 Alexander Fleming 1945 NP 完全改变了人类与传染病生死搏斗的历史 C C O NH N S H H H COOH H H O Penicillin 来自微生物的药物Penicillin: The Magic Bullet Ernst Boris Chain Howard Walter Florey “神奇药物”应该提早10年问世？ Robison and Woodward