河北医科大学：《天然药物化学》课程教学资源（课件讲稿）天然药物化学的魅力 13/13

Antibiotic without Detectable Resistance 人体就是一个“炼丹炉” Lactocillin C.2014./5:1402-1 Dr.Kim Lewis No University of Califori Cocoa flavanols can reverse memory loss Anthracimycin-Kills Anthrax in Older Adults s also the Cure for Caneer at the Bottom of the Sea Scientists Discover First Virological Penicillin Zhang ChenYu,Cell Research 2015.25:39-4 Tetrandrine:Shows Promise for Good-looking Molecule Blocking Ebola Virus

1 Antibiotic without ntibiotic without Detectable etectable Resistance esistance Dr. Kim Lewis Northeastern University Nature, 2015, 517, 455-9. O HN H N O O OH O NH2 O N H O H N O OH HN O NH O O NHHN O HN NH HN HN O O Teixobactin A break-through in nearly three decades 人体就是一个“炼丹炉” Lactocillin Michael A. Fischbach Cell, 2014,158:1402-14 University of California How the Germs in Your Body Keep You Health Lonicera japonica 金银花 H5N1 and H7N9 Cocoa Flavanols Flavanols Can Reverse Memory Loss Can Reverse Memory Loss in Older Adults in Older Adults Scientists Discover First ‘Virological Penicillin’ Zhang ChenYu, Cell Research 2015,25:39-49. Nature Neuroscience 2014, 17, 1798-1803. 张辰宇 博士 Lauren Paul and William Fenical Anthracimycin— Kills Anthrax Kills Anthrax 炭疽霉素 Bacillus anthracis 2001 Anthrax attacks O O O H O H H H H Anthracimycin Is also the Cure for Cancer at the Bottom of the Sea? 炭疽菌 Tetrandrine Tetrandrine: Shows Promise for : Shows Promise for Blocking Ebola Virus Blocking Ebola Virus 埃博拉 Ebola virus Science, 2015, 347, 995-8 N N OMe OMe MeO OMe H3C CH3 O O Tetrandrine 粉防己碱 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 Chemical Shift (ppm) 5.5 5.0 4.5 Chemical Shift (ppm) 2 10 5 9 OH-5,9,13 7a 6b 14b 19 18 16 17 Ac OH OH OAc AcO H HO O 3 11 4 13 1 6 9 18 15 19 20 14 12 7 5 10 H 16 17 Good-looking Molecule looking Molecule

H-NMR Speetrum of Echinopine A A Cell Is Like A Factory A 兰 与传有机合成相比坐物合成具有行少不使用有能有机相愿 社量化生产代表来来爱是方肉 Beat Diseases with a better Diet What can we learn from Nature? New Lifestyle-Plants/Vegetable as Medicine 谢谢大家 2

2 12 11 10 9 8 7 6 5 4 3 2 1 0 Chemical Shift (ppm) Chloroform-d 11 10 9 Chemical Shift (ppm) 4.625 Chemical Shift ... 1H-NMR Spectrum of NMR Spectrum of Echinopine Echinopine A 2.5 2.0 1.5 1.0 0.5 Chemical Shift (ppm) KCN's 39 steps OCH3 O H H H A Cell Is Like A Factory A Cell Is Like A Factory 与传统有机合成相比, 生物合成具有污染少, 不使用有毒的有机试剂, 原料易得 便宜、对生产仪器要求低、容易进行批量化生产, 代表未来发展方向。 Beat Diseases with A Better Diet Beat Diseases with A Better Diet Nature is a productive biochemical factory for the biosynthesis of Nat. Prod. New Lifestyle—Plants/Vegetable as Medicine Diabetes & Cancer Buster 谢 谢 大 家 河北医科大学药学院 天然药物化学教研室 http://202.206.48.73/tryw1/default.asp What can we learn from Nature？ Only One