河北医科大学：《天然药物化学》课程教学资源（课件讲稿）天然药物化学概论 Medicinal Natural Product Chemistry

阿业医绅女学 HEBEI MEDICAL UNIVERSITY 天然药物化学 Medicinal Natural Product Chemistry 史清请文教授 http://202.206.48.73/tryw1/default.asp

史清文 教授 天 然 药 物 化 学 Medicinal Natural Product Chemistry Medicinal Natural Product Chemistry http://202.206.48.73/tryw1/default.asp

Question 1 What we have learn?

What we have learn? Question 1

Question 2 Why we study this course?

Why we study this course? Question 2

大自然才是真正的化学全合成大师 H OH H3C OH OH Huperzine A Qinghaosu Ginkgolide C Vinigrol 石杉碱甲 青蒿素 银杏叶内酯C OH H OO OH NH H H3C-N OH HO OH Quinine奎宁 Morphine吗啡 Strychnine Tetrodotoxin 马钱子碱 河豚毒素 AcO H3C- OH H3C-0 HO、 CH Ph 0、0 OH Aconitine Ajmaline Ph Lycopodine 乌头碱 萝芙木碱 石松碱 Taxol紫杉醇

大自然才是真正的化学全合成大师 大自然才是真正的化学全合成大师 N O H H Lycopodine 萝芙木碱 石松碱 N N OH OH H H CH3 Ajmaline N OH O CH3 OH O Ph O HO H3C O O H3C O H3C O H3C O H3C Aconitine 乌头碱 O O O O HO O O HO O HO H OH H H Ginkgolide C O O O O O CH3 H3C H3C Qinghaosu OH OH OH Vinigrol N N O O H H H H H Strychnine N H N OO OH H NH HO OH HO OH H OH Tetrodotoxin N OH OH O H3C Morphine H HO AcO H O H O O O H OH OAc H O O OH H N O Ph H H H Taxol H N CH3 H3C O NH2 Huperzine A N N H H HO H3CO H Quinine 奎宁 马钱子碱 河豚毒素 吗啡 紫杉醇 石杉碱甲 青蒿素 银杏叶内酯C

Drug Discovery:Finding a Lead

Drug Discovery: Finding a Lead

Question 3 Why synthesize so many interesting compounds (Secondary Metabolites)in nature? 夹竹桃 Evolution gave different organism different "Chemical Tools"to communicate with individuals of the same specie or to defend themselves against predators. s“Chemical Warfare

Evolution gave different organism different “Chemical Tools” to communicate with individuals of the same specie or to defend themselves against predators. 夹竹桃 Why synthesize so many interesting compounds (Secondary Metabolites) in nature? Question 3 ‘‘Chemical Warfare’’

Question 4 Why so many compounds in nature have biological effects to humans?

Question 4 Why so many compounds in nature have biological effects to humans?

As we share the same kind of Primary Metabolism, 。So those“Chemical Tools”have a effect on the human body. And some times those“Chemical Tools'”can be used as Medicinal Drugs

• As we share the same kind of Primary Metabolism, • So those “Chemical Tools” have a effect on the human body. And some times those “Chemical Tools” can be used as Medicinal Drugs

Question 5 Who pave the way in this field in our country?

Who pave the way in this field in our country? Question 5

中草药成分化学研究的开拓者和奠基人 赵承嘏 朱子清 曾广方 陈克恢 张昌绍 (1885-1966 (1900-1989) (1902-1979) (1898-1988) (1906-1967) 1914日内瓦大学 1933伊利诺大学 1931东京大学 1923威斯康辛大学 1940伦教大学 庄长恭1894-1962 美达衡1905-1987 朱任宏(1900-) 梅斌夫(1900-1992) 1924芝加哥大学许植方(1897-1982)1938柏林大学 1924东南大学 1926金陵大学

中草药成分化学研究的开拓者和奠基人 中草药成分化学研究的开拓者和奠基人 赵承嘏 (1885-1966) 曾广方 陈克恢 张昌绍 (1902-1979) 1931东京大学 1923威斯康辛大学 (1898-1988) (1906-1967) 1940伦敦大学 (1900-1989) 朱子清 1933伊利诺大学 姜达衢 1905-1987 1938柏林大学 朱任宏 (1900-) 许植方 (1897-1982) 1914日内瓦大学 1924东南大学 梅斌夫 (1900-1992) 1926金陵大学 庄长恭 1894-1962 1924芝加哥大学