麻省理工大学：《蛋白质标志—分解机制与人类疾病》（英文版）Introductory slides for Session 6

Introductory slides for Session 6 mages removed due to copyright considerations. See the following Figure 1 and Table 1 in Reed Sl. 2003. Ratchets and clocks: The cell cycl ubiquitylation and protein turnover. Nat. Rev. Mol. Cell BioL. 4: 855-864 Figure 1 in Bartek J, Lukas J Mammalian G1-and S-phase checkpoints in response to DNA damage. Curr Opin Cell Biol. 2001 Dec; 13(6): 738-47

Introductory slides for Session 6 Images removed due to copyright considerations. See the following: Figure 1 and Table 1 in Reed SI. 2003. Ratchets and clocks: The cell cycle, ubiquitylation and protein turnover. Nat. Rev. Mol. Cell Biol. 4: 855-864. Figure 1 in Bartek J, Lukas J. Mammalian G1- and S-phase checkpoints in response to DNA damage. Curr Opin Cell Biol. 2001 Dec;13(6):738-47

Images removed due to copyright considerations. See the following Figure 1 and Table 1 in Reed SL. 2003. Ratchets and clocks: The cell cycle ubiquitylation and protein turnover. Nat. Rev. Mol. Cell BioL. 4: 855-864 Figure 1 in Bartek J, Lukas J Mammalian G1-and S-phase checkpoints in response to DNA damage. Curr Opin Cell BioL. 2001 Dec; 13(6): 738-47

Images removed due to copyright considerations. See the following: Figure 1 and Table 1 in Reed SI. 2003. Ratchets and clocks: The cell cycle, ubiquitylation and protein turnover. Nat. Rev. Mol. Cell Biol. 4: 855-864. Figure 1 in Bartek J, Lukas J. Mammalian G1- and S-phase checkpoints in response to DNA damage. Curr Opin Cell Biol. 2001 Dec;13(6):738-47

Stress Glucocorticoids Receptor Receptor Survival (Radiation) Ubiquitination Mdm2 nation ubiquitination Image removed for copyright considerations Oncogene. The Bcl-2 family roles in cell survival and Ubiquitination Bc|-2 oncogenesIs.2003Nov2422(53):8590-607 Ubiquitination Smac/Diablo Cytochrome c NEXB Degradation Ubiquitination Caspase-Dependent Apoptosis Pathway Figure by MIT OCW. After Yang and Xu, "Regulation of apoptosis the ubiquitous way " FASEB J 17(2003)790-799 cytochrome c Apaf-1 Death Receptor-ligand interactions Regulated by cytokines and hormones mitochondria Cell Injury initiator Caspases Na dama Execution Caspases Catabolism of cytoskeleton ELL DEATH nucleus Courtesy of Dr. Jeremy Hughes. Used with permission Source:"apoptosis,"http:/mWww.portfolio.mvm.ed.ac.uk/studentwebs/session2/group28/index.html

Image removed for copyright considerations. Source: Fig.3 in Cory S, Huang DC, Adams JM. Oncogene. The Bcl-2 family: roles in cell survival and oncogenesis. 2003 Nov 24;22(53):8590-607. Figure by MIT OCW. After Yang and Xu, "Regulation of apoptosis: the ubiquitous way." FASEB J 17 (2003) 790-799. Courtesy of Dr. Jeremy Hughes. Used with permission. Source: "Apoptosis," http://www.portfolio.mvm.ed.ac.uk/studentwebs/session2/group28/index.html