安徽医科大学：《临床药理学 Clinical Pharmacology》课程教学资源（课件讲稿，英文版）临床药理学概论 Introduction to clinlcal pharmacology（主讲：魏伟）

Introduction to Clinical Pharmacology 临床药理学概论 绘做医降大学临床药埋研究 Prof.Wei Wei HUI 魏伟 Institute of Clinical Pharmacology Anhui Medical University Key Laboratory of Anti-Inflammatory and Immune Medicine of Education Ministry,China

Introduction to Clinical Pharmacology 临床药理学概论 Prof. Wei Wei 魏 伟 Institute of Clinical Pharmacology Anhui Medical University Key Laboratory of Anti-Inflammatory and Immune Medicine of Education Ministry, China

Pharmacology has multiple branch Neuropsycho- Cardiovascular Endocrine Anti-inflammatory- pharmacology Pharmacology Pharmacology Immunopharmacology Tma hau Tumor Chemotherapy Biochemical Pharmacometrics Clinical Pharmacology Pharmacology Molecular Pharmacology Pharmacology

Pharmacology has multiple branch Neuropsycho- Cardiovascular Endocrine Anti-inflammatory￾pharmacology Pharmacology Pharmacology Immunopharmacology Tumor Chemotherapy Biochemical Pharmacometrics Clinical Pharmacology Pharmacology Molecular Pharmacology Pharmacology

What's the Clinical Pharmacology? O is the science of drugs and their clinical use. O has a broad scope,from the discovery of new target molecules,to the effects of drug usage in whole populations. O connects the gap between medical practice and laboratory science. O It is a subject to study the interaction between drugs and humans.(This is the definition of clinical pharmacology) The main objective is to promote the safety of prescription,maximise the drug effects and minimise the side effects

What’s the Clinical Pharmacology? ○ is the science of drugs and their clinical use. ○ has a broad scope, from the discovery of new target molecules, to the effects of drug usage in whole populations. ○ connects the gap between medical practice and laboratory science. ○ It is a subject to study the interaction between drugs and humans. (This is the definition of clinical pharmacology) The main objective is to promote the safety of prescription, maximise the drug effects and minimise the side effects

Clinical Pharmacology ■ involves all aspects of the relationship between drugs and humans,including O the discovery and development of new drugs, O the application of drugs as therapeutic agents, O the beneficial and harmful effects of drugs in individuals and society, ●the misuse of drugs. ■ Clinical pharmacology is a multidisciplinary science, including ●medicine, ●pharmacology, ●pharmacy, World Health Organization IUPHAR ●biomedical science International Union of Basic and Clinical Pharmacelogy ●nursing. ■ Other professionals who are important in various aspects of clinical pharmacology,including O social and behavioural scientists, ●dentists, Council for International ● economists,O epidemiologists, MS Organizations of Medical Sciences ●】 geneticists,toxicologists, (CIOMS). mathematicians O computer scientists. Basic and Clinical Pharmacology and Toxicology(BCPT)in 2010,Volume 107,pages 531-559

Clinical Pharmacology ：
involves all aspects of the relationship between drugs and humans，including ● the discovery and development of new drugs, ● the application of drugs as therapeutic agents, ● the beneficial and harmful effects of drugs in individuals and society, ● the misuse of drugs.
Clinical pharmacology is a multidisciplinary science， including ● medicine, ● pharmacology, ● pharmacy, ● biomedical science ● nursing.
Other professionals who are important in various aspects of clinical pharmacology， including ● social and behavioural scientists, ● dentists, ● economists, ● epidemiologists, ● geneticists, ● toxicologists, ● mathematicians ● computer scientists. Basic and Clinical Pharmacology and Toxicology (BCPT) in 2010, Volume 107, pages 531 – 559. Council for International Organizations of Medical Sciences (CIOMS)

Course Focus Scientific basis of drug use, Development and evaluation. ·Vot therapeutics. Principles of drugs use

Course Focus • Scientific basis of drug use, Development and evaluation. • Not therapeutics. • Principles of drugs use

Contents of Clinical Pharmacology ●Clinical Pharmacodynamics(临床药效学) Aspirin plays a role in antiinflammation,antipyretic and analgesic via inhibiting prostaglandins(PGs)synthesis. ●Clinical Pharmacokinetics（临床药动学) absorption,distribution,metabolism and excretion of a drug. ●Rational Prescribing(合理用药) using the right medication,at the right dose, using the right route and frequency of administration for the patient, stopping the drug appropriately

Contents of Clinical Pharmacology ● Clinical Pharmacodynamics （临床药效学 ） - Aspirin plays a role in antiinflammation, antipyretic and analgesic via inhibiting prostaglandins (PGs) synthesis. ● Clinical Pharmacokinetics（临床药动学 ） - absorption, distribution, metabolism and excretion of a drug. ● Rational Prescribing (合理用药 ） - using the right medication, at the right dose, - using the right route and frequency of administration for the patient, - stopping the drug appropriately

●Toxicology and Adverse Drug Reaction(药物不良反应) is an expression that describes harm associated with the use of given medications at a normal dosage during normal use. ●Drug Interaction(药物相互作用) is a situation in which a substance (usually another drug)affects the activity of a drug when both are administered together. ●Drug development(药物开发) It includes pre-clinical research (on microorganisms/animals)and clinical trials(on humans)and may include the step of obtaining regulatory approval to market the drug

● Toxicology and Adverse Drug Reaction （药物不良反应 （药物不良反应） - is an expression that describes harm associated with the use of given medications at a normal dosage during normal use. ● Drug Interaction（药物相互作用 （药物相互作用） - is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. ● Drug development (药物开发） - It includes pre-clinical research (on microorganisms/animals) and clinical trials (on humans) and may include the step of obtaining regulatory approval to market the drug

Career goals of clinical pharmacologists Optimize understanding and use of existing medicines. Develop and evaluate new medicines

Career goals of clinical pharmacologists • Optimize understanding and use of existing medicines. • Develop and evaluate new medicines

Teaching Contents Unit 1: :Introduction to Clinical Pharmacology(绪论) Unit 2:Clinical Pharmacokinetics (associate prof.Wu-yi Sun) (临床动力学) Unit 3:Drug Discovery Development(prof.Ling-ling Zhang) (药物的发现与研发) Unit 4:Clinical Drug Effect Assessment(prof.Qing-tong Wang) (药效评价) Unit 5:Principles of drug use for special populations (特殊人群用药)(associate prof.Jing-yu Chen) Unit 6:Clinical Pharmacogenetics,(associate prof.Yan Chang) Drug interactions,Drug toxicology (临床遗传药理学、药物相互作用、药物毒理学)

Teaching Contents Unit 1: Introduction to Clinical Pharmacology (绪论 ) Unit 2:Clinical Pharmacokinetics (associate prof. Wu-yi Sun) (临床动力学 ) Unit 3: Drug Discovery & Development (prof. Ling-ling Zhang) （药物的发现与研发 药物的发现与研发 ） Unit 4:Clinical Drug Effect Assessment (prof. Qing-tong Wang) （药效评价 ） Unit 5:Principles of drug use for special populations (特殊人群用药 ) (associate prof. Jing-yu Chen) Unit 6: Clinical Pharmacogenetics, (associate prof. Yan Chang) Drug interactions, Drug toxicology (临床遗传药理学、药物相互作用 、药物相互作用、药物毒理学 )

Unit 1 Introduction to Clinical Pharmacology Aims and Requirements To master the concept of clinical pharmacology and the research contents of clinical pharmacology. Have a general concept about the development of clinical pharmacology and the career goals of clinical pharmacologists. Teaching contents Concept of clinical pharmacology. Important history events of modern pharmacology Development of clinical pharmacology. The relationship between health,disease and drug. General concept of clinical pharmacokinetics and clinical pharmacodynamics. Hot spots in research of clinical pharmacology

Unit 1 Introduction to Clinical Pharmacology Aims and Requirements To master the concept of clinical pharmacology and the research contents of clinical pharmacology. Have a general concept about the development of clinical pharmacology and the career goals of clinical pharmacologists. Teaching contents □ Concept of clinical pharmacology. □ Important history events of modern pharmacology. □ Development of clinical pharmacology. □ The relationship between health, disease and drug. □ General concept of clinical pharmacokinetics and clinical pharmacodynamics. □ Hot spots in research of clinical pharmacology