安徽医科大学：《临床药理学 Clinical Pharmacology》课程教学资源（授课教案，英文版）Time Course of Drug Response

安徽医科大学国际教育学院教案与讲稿 Teaching Plan for International Students,AHMU Title of the course:Time Course of Drug Response Chapter:_ 19 Teacher's name: Dr.Qingtong Wang Grade: 2013 Department:School of International Education Time:14:30-16:50 Date(D/M/Y):3/23/2016 Teaching 1.Master the characteristic of time course of drug action Objectives; 2.Recognize the time course types of individual drugs Teaching Requirements Teaching 1.Immediate drug effects 2.Delayed drug effects Content 3.Cumulative drug effects Teaching Teaching Focus:the characteristic of time course of drug action:Immediate drug effects,delayed drug effects,cumulative drug effects Focus; Difficult Difficult Problems:what is time course of drug,its classification,and the function in drug treatment? Problems Solutions:Show representative figures to explain the time course of drug and their action,give examples to introduce the characteristic of individual drugs in Solutions detail. 1.Immediate drug effects 10min Time 2.Delayed drug effects 7min Allotment 3.Cumulative drug effects 13 min Assignment Use examples to elucidate time course of drug action. 1.Principle of Clinical Pharmacology (Second Edition);ArthurJ.Atkinson Reference 2.Basic Clinical Pharmacology;Bertram G Katzung Text 3.Oxford Textbook of Clinical Pharmacology and Drug Therapy;David Grahame-Smith,Jeffrey Aronson Memo Teaching Plan for International Students,AHMU 1

安徽医科大学国际教育学院教案与讲稿 1 Teaching Plan for International Students, AHMU Title of the course: Time Course of Drug Response Chapter: 19 Teacher’s name: Dr. Qingtong Wang Grade: 2013 Department: School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/23/2016 Teaching Objectives; Teaching Requirements 1. Master the characteristic of time course of drug action 2. Recognize the time course types of individual drugs Teaching Content 1. Immediate drug effects 2. Delayed drug effects 3. Cumulative drug effects Teaching Focus; Difficult Problems and their Solutions Teaching Focus: the characteristic of time course of drug action: Immediate drug effects, delayed drug effects, cumulative drug effects Difficult Problems: what is time course of drug, its classification, and the function in drug treatment? Solutions: Show representative figures to explain the time course of drug action, give examples to introduce the characteristic of individual drugs in detail. Time Allotment 1. Immediate drug effects 10 min 2. Delayed drug effects 7 min 3. Cumulative drug effects 13 min Assignment Use examples to elucidate time course of drug action. Reference Text 1. Principle of Clinical Pharmacology (Second Edition); ArthurJ. Atkinson 2. Basic & Clinical Pharmacology; Bertram G. Katzung 3.Oxford Textbook of Clinical Pharmacology and Drug Therapy; David Grahame-Smith, Jeffrey Aronson Memo Teaching Plan for International Students, AHMU

安微医科大学国际教育学院教案与讲稿 Title of the course: Time Course of Drug Response Chapter: 19 Teacher's name: Dr.Qingtong Wang Grade:2013 Department:School of International Education Time:14:30-16:50 Date (D/M/Y): 3/23/2016 Lecture Notes: [INTRODUCTION] 2min Drug dose--Drug concentration--Drug exposure Immediate Drug Effects Delayed Drug Effects Cumulative Drug Effects [IMMEDIATE DRUG EFFECTSI 2min Drug Action Potentiation of GABA receptor activation Drug Effect Slowing of EEG activity Drug Response Anesthesia Response in Minutes EXAMPLESI 6min Thiopentone time course [DELAYED DRUG EFFECTSI 3min Drug Action:inhibition of Vit K recycling Drug Effect:decreased synthesis of clotting factors Drug Response:prolonged coagulation time [PHYSIOKINETIC DELAYED RESPONSE 4min Angiotension Converting Enzyme Inhibitors(enalapril) Delayed effect on blood pressure(1 week) Half-life of Na+is about 2 days Anti-Depressants(amitriptyline) Delayed effect on depression(2 weeks) Unidentified mediator A protein with a 4 day half-life? [CUMULATIVE DRUG RESPONSE] 2min Action:inhibition of gastric acid pump Effect:decreased acid secretion and increased pH Response:ulcer healing 2

安徽医科大学国际教育学院教案与讲稿 2 Title of the course: Time Course of Drug Response Chapter: 19 Teacher’s name: Dr. Qingtong Wang Grade: 2013 Department: School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/23/2016 Lecture Notes: [INTRODUCTION] 2min Drug dose--Drug concentration--Drug exposure Immediate Drug Effects Delayed Drug Effects Cumulative Drug Effects [IMMEDIATE DRUG EFFECTS] 2min Drug Action Potentiation of GABA receptor activation Drug Effect Slowing of EEG activity Drug Response Anesthesia Response in Minutes [EXAMPLES] 6min Thiopentone time course [DELAYED DRUG EFFECTS] 3min Drug Action: inhibition of Vit K recycling Drug Effect: decreased synthesis of clotting factors Drug Response: prolonged coagulation time [PHYSIOKINETIC DELAYED RESPONSE] 4min Angiotension Converting Enzyme Inhibitors (enalapril) Delayed effect on blood pressure (1 week) Half-life of Na+ is about 2 days Anti-Depressants (amitriptyline) Delayed effect on depression (2 weeks) Unidentified mediator A protein with a 4 day half-life? [CUMULATIVE DRUG RESPONSE] 2min Action: inhibition of gastric acid pump Effect: decreased acid secretion and increased pH Response: ulcer healing

安徽医科大学国际教育学院教案与讲稿 ICUMULATIVE DRUG RESPONSEI lmin Takes several weeks of acid inhibition to heal an ulcer Acid inhibition effect is constant but the Response continues to develop(e.g.smaller size of ulcer) Response time course is(almost)independent of drug dose/concentration when inhibition is nearly 100% [CUMULATIVE DRUG RESPONSE] 2min Diuretics are used to treat heart failure with digoxin and ACE inhibitors Symptoms are produced by excess fluid Ascites,edema,breathlessness,ankle swelling,(dropsy) Benefit is related to reduction in fluid [CUMULATIVE DRUG RESPONSE 3min Action Inhibition of Na*reabsorption Effect Increased Na+and H20 excretion Cumulative fluid loss Response Reduced ankle swelling Decreased breathlessness [CMULATIVE DRUG EFFECTS] 2min Response is NOT proportional to cumulative diuretic dose or AUC Response IS proportional to cumulative diuretic effect or AUCe Phenomenon is known as Schedule Dependence" [CUMULATIVE DRUG RESPONSE] 3min Anti-Cancer Agents Schedule Dependence is ·Action common -Irreversible binding to cell structure Large intermittent doses are often more toxic and less Effect effective than smaller repeated doses Block of cell division/cell death Slowing or reversal of Response is related to tumour growth cumulative dose as well as schedule Response AUC may be used to guide -Decreased morbidity (e.g. Pain) individual treatment Postponement of death 3

安徽医科大学国际教育学院教案与讲稿 3 [CUMULATIVE DRUG RESPONSE] 1min Takes several weeks of acid inhibition to heal an ulcer Acid inhibition effect is constant but the Response continues to develop (e.g. smaller size of ulcer) Response time course is (almost) independent of drug dose/concentration when inhibition is nearly 100% [CUMULATIVE DRUG RESPONSE] 2min Diuretics are used to treat heart failure with digoxin and ACE inhibitors Symptoms are produced by excess fluid Ascites, edema, breathlessness, ankle swelling, (dropsy) Benefit is related to reduction in fluid [CUMULATIVE DRUG RESPONSE] 3min Action Inhibition of Na+ reabsorption Effect Increased Na+ and H2O excretion Cumulative fluid loss Response Reduced ankle swelling Decreased breathlessness [CMULATIVE DRUG EFFECTS] 2min Response is NOT proportional to cumulative diuretic dose or AUC Response IS proportional to cumulative diuretic effect or AUCe Phenomenon is known as Schedule Dependence” [CUMULATIVE DRUG RESPONSE] 3min Anti-Cancer Agents