《分子生物》（参考） Introduction of Molecular Biology

ntroduction of Molecular Biology Genomics 中心法则 Proteomics DNA PROTEIN RNA Functional genomics

Introduction of Molecular Biology 中心法则 RNA PROTEIN DNA Genomics Functional genomics Proteomics

An introduction of gene function I Storing information 2、 Replication 3、 Mutation

An introduction of gene function 1、Storing Information 2、Replication 3、Mutation

Overview of gene expression Gene: ATGAGTAACGCG Nontemplate strand TACTCATTG CGC Template strand Transcription mRNA: AUGAGUAACGCG Translation Protein: MetSerAsnAla

Overview of gene expression

H O H O H O H2N-C-C-0-++HN-C-C-0 H3N-C-C-N-c-C-0+ H20 Peptide bond 肽键的形成

肽键的形成

) ( NOOOO(R an example of protein secondary structure: a-helix

an example of protein secondary structure: а -helix

Carboxyl terminal R terminal N 二D R) R Carboxyl Amino terminal terminal An antiparallel B-sheet

An antiparallel β -sheet

tertiary structure of myoglobin(肌红蛋白)

tertiary structure of myoglobin(肌红蛋白)

The globular domains of immunoglobulin quaternary structure)

The globular domains of immunoglobulin ( quaternary structure )

summary y Proteins are polymers of amino acids linked through peptide bonds y The sequence of amino acids in a polypeptide imary structure)gives rise to that molecules local shape(secondary structure,overall shape (tertiary structure), and interaction with other polypeptides(quaternary structure)

summary  Proteins are polymers of amino acids linked through peptide bonds .  The sequence of amino acids in a polypeptide (primary structure) gives rise to that molecule , s local shape (secondary structure),overall shape (tertiary structure), and interaction with other polypeptides (quaternary structure)

Transcription (1)Initiation (a) RNa polymerase binds N OVVYVMN to promoter (b)First phosphodiester bond forms (2)Elongation (3)Termination

Transcription