《生物化学 Biochemistry》课程教学资源（双语教程PPT）Chapter 2 ProteinSection1 Amino Acids

CHAPTER2 PROTEIN Sectionl amino acids

CHAPTER 2 PROTEIN Section1 Amino Acids

Outline 4. 1: Amino Acids: Building blocks of Proteins 4.2: Acid-Base Chemistry of Amino Acids 4.3 Reactions of amino acids 4.4: Optical activity and stereochemistry of Amino acids 4.5: Spectroscopic properties of Amino Acids 4.6: Separation and analysis of a a Mixtures

Outline 4.1: Amino Acids: Building Blocks of Proteins 4.2: Acid-Base Chemistry of Amino Acids 4.3: Reactions of Amino Acids 4.4: Optical Activity and Stereochemistry of Amino Acids 4.5: Spectroscopic Properties of Amino Acids 4.6: Separation and Analysis of a.a. Mixtures

Amino acids Building Blocks of proteins Side H R chain a-Carbon HN COo COO Amino Carboxyl Ball-and-stick group group model R Amino acids are tetrahedral structures

Amino Acids Building Blocks of Proteins

6 05 CH2—CH2—CH2—CH2-CH—COO nHS +nH3 Lysine In protein chemistry, we use Greek letter nomenclature. ----C-C-C-C-COOH Y阝a ·-C-C-C-C(NH2)-COOH a-Amino acid ----C-C-C (NH2)-C-CooH B-Amino Acid ----C-C (nH2) -C -C-COOH y-Amino Acid

• ----C-C-C-C-COOH • γ β α • ----C-C-C-C(NH2 )-COOH α- Amino Acid • ----C-C-C (NH2 )- C - COOH β- Amino Acid • ----C-C (NH2 )- C - C - COOH γ- Amino Acid In protein chemistry, we use Greek letter nomenclature

Amino Acids Can Join via peptide bonds Tw amino acids d Remost at a water moEen + Perrine bond formation of the CHNH Amino end Carboxy end

Amino Acids Can Join Via Peptide Bonds

20 Common Amino acids You should know names, structures, pka values, 3-letter and -letter codes Non-polar amino acids Polar, uncharged amino acids Acidic amino acids Basic amino acids

20 Common Amino Acids You should know names, structures, pKa values, 3-letter and 1-letter codes • Non-polar amino acids • Polar, uncharged amino acids • Acidic amino acids • Basic amino acids

Non-polar amino acids COOH CH Alanine(Ala, A) COOH HSN-C--H CH CH Valine (Val, V)

•Non-polar amino acids

COOH H.NtC-H CH CH Leucine (Leu, L) COoH H,N-C-l HC-C-H CH, Isoleucine (lle, 1)

COOH 时N-C-H H,C CH CHe Proline (Pro, P) COOH HeN'-C-H CH Phenylalanine (Phe, F

COoH H.NT-C-H CH CH Tryptophan (Trp, w) COoH H3N′-C-H CH CH Methionine (MeL. M)