山东大学基础医学院：《生理学 Physiology》课程PPT教学课件_The Nervous System 神经系统（含感觉器官）神经系统对内脏功能调节 Regulation of the Visceral Function by the Nervous System

Chapter 33 Regulation of the visceral function by the Nervous System

Chapter 33 Regulation of the Visceral Function by the Nervous System

I Autonomic Nervous system 1. Basic of the Anatomy

I Autonomic Nervous System 1. Basic of the Anatomy

Autonomic Nervous System o Including parasympathetic, sympathetic, and enteric divisions o Coordinates cardiovascular, respiratory digestive, excretory and reproductive systems o The enteric system is essentially an independent nervous system responsible for regulation of digestive functions

Autonomic Nervous System ⚫ Including parasympathetic, sympathetic, and enteric divisions. ⚫ Coordinates cardiovascular, respiratory, digestive, excretory and reproductive systems. ⚫ The enteric system is essentially an independent nervous system responsible for regulation of digestive functions

Somatic and Autonomic Nervous System Companies, Inc. Permi Spinal nerve Spinal cord Somatic Skeletal muscle motor neuron Spinal nerve Autonomic ganglion Spinal cord Effector organ Preganglionic Postganglionic (e. g, neuron neuron smooth muscle b of colon

Somatic and Autonomic Nervous System

Somatic and autonomic Nervous system Somatic autonomic Skeletal muscle Smooth and cardiac muscle and glands ● Conscious and Unconscious regulation unconscious movement Target tissues stimulated e Skeletal muscle contracts or inhibited o One synapse Two synapses acetylcholine Acetycholine by preganglionic neurons and ACh or norepinephrine by postganglionic neurons

Somatic and Autonomic Nervous System Somatic ⚫ Skeletal muscle ⚫ Conscious and unconscious movement ⚫ Skeletal muscle contracts ⚫ One synapse ⚫ Acetylcholine Autonomic ⚫ Smooth and cardiac muscle and glands ⚫ Unconscious regulation ⚫ Target tissues stimulated or inhibited ⚫ Two synapses ⚫ Acetycholine by preganglionic neurons and ACh or norepinephrine by postganglionic neurons

Preganglionic cell body in lateral horn of Preganglionic neuron gray matter Postganglionic neuron Preganglionic neuron to sympathetic chain ganglion Postganglionic neurons Preganglionic neuron to collateral ganglion 侧副神经节 L2 Postganglionic neurons 9●- Collateral Sympathetic ganglia Division Sympathetic chain ganglia e Preganglionic cell bodies in lateral horns of spinal cord T1-L2

⚫ Preganglionic cell bodies in lateral horns of spinal cord T1-L2 Sympathetic Division 侧副神经节

Parasympathetic Division Preganglionic cell bodies in nuclei of brainstem or sYt+Midbrain Cranial nerves lateral parts of spinal cord Pons Brainstem Medulla (S2S4) Preganglionic axons Preganglionic from brain pass to Postganglionic neuron neurons Postganglionic ganglia through cranial Terminal ganglia neuron nerves Preganglionic neurons Sacral region Preganglionic axons Pelvic nerves of spinal cord (s2-S4) from sacral region pass through pelvic nerves to ganglia o Preganglionic axons pass to ganglia within wall of or near organ innervated

Parasympathetic Division ⚫ Preganglionic cell bodies in nuclei of brainstem or lateral parts of spinal cord （S2-S4） – Preganglionic axons from brain pass to ganglia through cranial nerves – Preganglionic axons from sacral region pass through pelvic nerves to ganglia ⚫Preganglionic axons pass to ganglia within wall of or near organ innervated

parasympathetic Sympathetic Parasympathetic Lacrimal, mandibular and sublingual glands and sympathetic Parotid and mandibular glands Cranial cervical ganglion nerve distribution Larynx, esophagus and trachea ddle cervical ganglion Vagus n Bronchi and lungs To brachial Cervicothoracic ganglion trunk gan Sympathetic trunk splanchnic n. Abdominal viscera Cranial mesenteric nd plexus Hypogastric n. genial organs To pelvic plexus

Parasympathetic and sympathetic nerve distribution

2. Neurotransmitters and Neuroreceptors o Acetylcholine and Norepinephrine ●△ I preganglionic neurons are cholinergic o Parasympathetic post ganglionic neurons are cholinergic o Sympathetic post ganglionic neurons are adrenergic exce ept Sympathetics innervating sweat glands, blood vessels in skeletal muscle, and piloerection muscles are cholinergic

2. Neurotransmitters and Neuroreceptors ⚫ Acetylcholine and Norepinephrine ⚫ All preganglionic neurons are cholinergic ⚫ Parasympathetic post ganglionic neurons are cholinergic ⚫ Sympathetic post ganglionic neurons are adrenergic except – Sympathetics innervating sweat glands, blood vessels in skeletal muscle, and piloerection muscles are cholinergic

Neurotransmitters SOMATIC NERVOUS SYSTEM ACh Striated muscle AUTONOMIC NERVOUS SYSTEM Sympathetic Heart ACh NESm、muS Glands ACh KACh Sweat glands <ACh (AdM. NE Parasympathetic Heart ACh <ACh Sm. mus Glands

Neurotransmitters ACh ACh Sweat glands Striated muscle ACh SOMATIC NERVOUS SYSTEM Heart Sm. mus. Glands ACh ACh Parasympathetic ACh E, NE Ad. M. → → Heart Sm. mus. Glands ACh NE AUTONOMIC NERVOUS SYSTEM Sympathetic