麻省理工大学：《Foundations of Biology》课程教学资源（英文版）Lecture 6 Structure Prediction

7.91- Lecture #6 Michael Yaffe Protein Secondary Structure Prediction

7.91 – Lecture #6 Protein Secondary Structure Prediction Michael Yaffe

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7.93 – Lecture #9 Protein Secondary Structure Prediciton -and￾Motif Searching with Scansite

Outline Brief review of protein structure Chou-Fasman predictions Garnier, Osguthorpe and robson Helical wheels and hydrophobic moments Neural networks Nearest neig hbor methods Consensus prediction approaches

Outline • Brief review of protein structure • Chou-Fasman predictions • Garnier, Osguthorpe and Robson • Helical wheels and hydrophobic moments • Neural networks • Nearest neighbor methods • Consensus prediction approaches

Hierarchy of protein structure Hierarchy of Protein Structure Primary Second F-I-P-A L-F-A-H K-E-L-A T-S-V TSKY Tertiary uaternary

Hierarchy of protein structure

Reasonance of peptide bond implies planarity Peptide bond C N H H R

implies planarity Reasonance of peptide bond

Dihedral angles define secondary structure Please refer to branden carl and john tooze, Introduction to protein structure 2nd ed. Garland Publishing, InC. 1999. ISBN: 0815323042

Dihedral angles define secondary structure Please refer to Branden, Carl, and John Tooze. Introduction to Protein Structure. 2nd ed. Garland Publishing, Inc., 1999. ISBN: 0815323042

Structure of a-helices Please refer to branden carl and John Tooze. Introduction to Protein structure 2nd ed. Garland Publishing, Inc, 1999. ISBN: 0815323042

Structure of α-helices Please refer to Branden, Carl, and John Tooze. Introduction to Protein Structure. 2nd ed. Garland Publishing, Inc., 1999. ISBN: 0815323042

a-helix dipole moment Please refer to branden carl. and John Tooze. Introduction to Protein structure 2nd ed Garland Publishing, Inc, 1999. ISBN: 0815323042

α-helix dipole moment Please refer to Branden, Carl, and John Tooze. Introduction to Protein Structure. 2nd ed. Garland Publishing, Inc., 1999. ISBN: 0815323042

Anti-parallel B-sheets Please refer to branden carl. and John Tooze. Introduction to Protein structure 2nd ed Garland Publishing, Inc, 1999. ISBN: 0815323042

Anti-parallel β-sheets Please refer to Branden, Carl, and John Tooze. Introduction to Protein Structure. 2nd ed. Garland Publishing, Inc., 1999. ISBN: 0815323042

The"pleat"a function of the tetrahedral Ca carbon Please refer to branden carl. and John Tooze. Introduction to Protein structure 2nd ed Garland Publishing, Inc. 1999. ISBN: 0815323042

The “pleat”- a function of the tetrahedral Cα carbon Please refer to Branden, Carl, and John Tooze. Introduction to Protein Structure. 2nd ed. Garland Publishing, Inc., 1999. ISBN: 0815323042