麻省理工大学：《Design of Medical Device》chapter 7 Tissue Engineering

CHAPTER 7 Tissue Engineering 7.1 Paradigms/strategies 7.2 Cells 7.3 Matrices 7. 4 Regulator

CHAPTER 7 Tissue Engineering 7.1 Paradigms/Strategies 7.2 Cells 7.3 Matrices 7.4 Regulators

7.1 ELEMENTS OF TISSUE ENGINEERING MATRICES (porous structures) Synthetic Polymers(absorbable) Polyactic acid Polyglycolic acid Natural Polymers(absorbable) Collagen(types l,Il, I,Iv) Collagen -GAG copolymer Fibrin Chitosa Synthetic Polymer(nonresorbable) PTFE Calcium Phosphate Natural minera Bone minera CELLS autole Marrow Stromal stem Cell Phenotypically Altered Cells Genetically altered Cells SOLUBLE REGULATOPRS Growth Factors(polypeptide mitogens) rs(e.g, BMP

7.1 ELEMENTS OF TISSUE ENGINEERING MATRICES (porous structures) Synthetic Polymers (absorbable) Polyactic acid Polyglycolic acid Natural Polymers (absorbable) Collagen (Types I, II, III, IV) Collagen - GAG copolymer Fibrin Chitosan Synthetic Polymer (nonresorbable) PTFE Synthetic Ceramics Calcium Phosphate Natural Mineral Bone Mineral CELLS Autologous Allogenic Marrow Stromal Stem Cell Phenotypically Altered Cells Genetically Altered Cells SOLUBLE REGULATOPRS Growth Factors (polypeptide mitogens) Differentiation Factors (e.g., BMP)

7.1 STRATEGIES FOR TISSUE ENGINEERING MATRICES EXOGENOUS TISSUE (Resorbable) REGULATORS CELLS CONNECTIVE TISSUE Collagen-GAG(C-G) PDGF Fibroblasts Dermis Polyactic Acid (PLa) FGF Polyglycolic Acid(PGA) TGF BONE Synthetc Hydroxyapatite(HA)BMP Marrow stromal stem Tricalcium Phosphate Cells Natural Bone mineral (Anorganic Bovine Bone) Collagen-HA/TCP Articular Cartilage C-G BMP Autologous Articular Chondrocytes PGA Allogeneic articular Chondrocyte Ligament Collagen fibers Fibroblasts PLA Fibers Tendon Collagen Fibers PLA Fibers C-G Meniscus EPITHELIA p nIs C-G EGF Epidermal cells PGA I(Keratinocytes) NERVE eripheral Silicone Tube Collagen Tube C-G Endothelial PGA Endothelial Cells PDFG-platelet derived growth factor; FGF-fibroblast growth factor; TGF-B-transforming growth factor; EGF-epidermal growth factor; BMP-bone morphogenetic protei

---- ---- ---- ---- ---- ---- ---- 7.1 STRATEGIES FOR TISSUE ENGINEERING TISSUE MATRICES (Resorbable) REGULATORS EXOGENOUS CELLS CONNECTIVE TISSUE Dermis Collagen-GAG (C-G) Polyactic Acid (PLA) Polyglycolic Acid (PGA) PDGF FGF TGF-b Fibroblasts BONE Synthetc Hydroxyapatite (HA) Tricalcium Phosphate Natural Bone Mineral (Anorganic Bovine Bone) PLA Collagen Collagen-HA/TCP BMP Marrow Stromal Stem Cells Articular Cartilage C-G Collagen PGA BMP Autologous Articular Chondrocytes Allogeneic Articular Chondrocytes Ligament Collagen Fibers PLA Fibers FGF Fibroblasts Tendon Collagen Fibers PLA Fibers C-G Meniscus C-G EPITHELIA Epidermis C-G PGA EGF Epidermal cells (Keratinocytes) NERVE Peripheral Endothelial Sillicone Tube Collagen Tube C-G PGA Endothelial Cells * PDFG-platelet derived growth factor; FGF-fibroblast growth factor; TGF-b-transforming growth factor; EGF-epidermal growth factor; BMP-bone morphogenetic protein