《环境工程微生物学》课程扩展资料（scientist microbiology from Harvard）An Ecological Approach to Microbes and Disease

An ecological approach tomicrobes and diseaseLS-HHMI OutreachProgram Summer WorkshopHarvard UniversityCambridge,MAJuly 10, 2008JonClardy,HarvardUniversityjon_clardy@hms.harvard.edu

An ecological approach to microbes and disease LS-HHMI Outreach Program Summer Workshop Harvard University Cambridge, MA July 10, 2008 Jon Clardy, Harvard University jon_clardy@hms.harvard.edu

Central dogma andbiological information flowDNARNAprotein

Central dogma and biological information flow DNA RNA protein

Small molecules and biological information flowNH2HCthiamineserotoninP20gH3smallDNARNAproteinmoleculesOHHOtestosteronerapamycinOHOCHOHO=estradiolOHHCOCH

Small molecules and biological information flow DNA RNA protein small molecules testosterone thiamine serotonin estradiol rapamycin N N S O P2O6H3 NH2 + N H HO NH2 OH HO OH O OH OCH3 O OH OCH3 O OCH3 O O O O N HO

RolesofsmallmoleculesDyingloblollypinesDendroctonusfrontalisSouthernpinebeetle(SPB)ImagesfromKierKlepzig(USDA-FS)andhttp://www.dartmouth.edu/~mpayres/photos.htm

Dying loblolly pines Roles of small molecules Images from Kier Klepzig (USDA-FS) and http://www.dartmouth.edu/~mpayres/photos.htm Dendroctonus frontalis Southern pine beetle (SPB)

Southern pine beetle (Dendroctonus frontalis)rice grainsouthernpinebeetleblackturpentinebeetle

southern pine beetle rice grain black turpentine beetle Southern pine beetle (Dendroctonus frontalis)

SPB attacks,pine counterattacksUGA0284024bTexasForestService(RonBillings)

SPB attacks, pine counterattacks Texas Forest Service (Ron Billings)

SPB callsforreinforcementsfrontalinUGA0284024bTexasForestService(RonBillings

SPB calls for reinforcements Texas Forest Service (Ron Billings) frontalin O O

Mass attack, victoryand spread001307UniversityofGeorgia(ChuckBargeron)UGA1247132GeorgiaForestryCommission(TerryPrice)VirginiaDepartmentofForestry(TimTigner）

Mass attack, victory and spread Georgia Forestry Commission (Terry Price) University of Georgia (Chuck Bargeron) Virginia Department of Forestry (Tim Tigner)

SPB gallery in the cambiumSPB larvaEntomocorticiumsp.(Es)ImagefromKierKlepzig(USDA-FS)

SPB gallery in the cambium SPB larva Entomocorticium sp. (Es) Image from Kier Klepzig (USDA-FS)

EntomocorticiumspSPBcarriesamutualisticfungusinthemycangium-aspecializedstructureinthefemale100

SPB carries a mutualistic fungus in the mycangium - a specialized structure in the female. Entomocorticium sp