《医学遗传学 Medical Genetics》课程PPT教学课件（英文版）Cancer Genetics

Medica, Genetics Cancer genetics

Cancer Genetics Medical Genetics

Cancer Cancer is a class of diseases caused by loss of cell cycle control. 8. In animals, cell numbers are under exquisite control Loss of this control leads to proliferation of unwanted cells .8 Cancer arises when the above situation reaches a certain degree

Cancer is a class of diseases caused by loss of cell cycle control. Cancer ❖ In animals, cell numbers are under exquisite control ❖ Loss of this control leads to proliferation of unwanted cells ❖ Cancer arises when the above situation reaches a certain degree

Cancer umor %o Cancer cells are malignant tumor (vs benign tumor) cells i all cancer cells are eventually capable of metastasis

Cancer & Tumor ❖ Cancer cells are malignant tumor (vs. benign tumor) cells ❖ All cancer cells are eventually capable of metastasis

Cancer Family Unusually large numbers of blood relatives develop certain kinds of cancers

Cancer Family Unusually large numbers of blood relatives develop certain kinds of cancers

Lynch Cancer Family syndrome Il Family g Italian family Warthin As. Heredity with reference to carcinoma. Arch Intern. Med. 1913. 12: 546-555 Hauser lJ, Weller C.VA further report on the cancer family of Warthin. Am J Cancer. 1936 27:434-449 Lynch HT, Krush AJ. Cancer family ' G revisited:1895-1970. Cancer.1971.27:1505-1511

Lynch Cancer Family Syndrome Ⅱ “Family G”: Italian family Warthin AS. Heredity with reference to carcinoma. Arch. Intern. Med. 1913. 12: 546-555 Hauser IJ, Weller C. VA further report on the cancer family of Warthin. Am. J. Cancer. 1936. 27: 434-449 Lynch HT, Krush AJ. Cancer family 'G' revisited: 1895-1970. Cancer. 1971. 27: 1505-1511

Lynch Cancer Family syndrome Il Family g Italian family MIM114400

Lynch Cancer Family Syndrome Ⅱ “Family G”: Italian family MIM 114400

Lynch Cancer Family syndrome Il Family g Italian family HNPCC: 18q11-q12 .o Adenocarcinomas of the colon Carcinoma of endometrium Gastric cancer, ovary cancer, breast cancer

Lynch Cancer Family Syndrome Ⅱ HNPCC: 18q11-q12 ❖ Adenocarcinomas of the colon “Family G”: Italian family ❖ Carcinoma of endometrium ❖ Gastric cancer, ovary cancer, breast cancer

Li-Fraumeni Syndrome Studies by Li and Fraumeni led to first evidence of inherited predisposition to cancer.(MIM 151623 Breast tumors .o Sarcoma, leukemia, lung cancer, and adrenal cortical carcinoma

Li-Fraumeni Syndrome Studies by Li and Fraumeni led to first evidence of inherited predisposition to cancer. (MIM 151623) ❖ Breast tumors ❖ Sarcoma, leukemia, lung cancer, and adrenal cortical carcinoma

Cancer Family 冷 Earlier age of onset s Multiple close relatives affected g Multiple primary tumours/bilateral di isease 8 Multiple tumours in specific cancer syndrome

Cancer Family ❖ Earlier age of onset ❖ Multiple close relatives affected ❖ Multiple primary tumours/bilateral disease ❖ Multiple tumours in specific cancer syndrome

Inherited Cancer Retinoblastoma, RB(MIM 180200 Retinoblastoma occurs sporadically in most cases, but in some families it displays autosomal dominant inheritance

Inherited Cancer Retinoblastoma, RB (MIM 180200) Retinoblastoma occurs sporadically in most cases, but in some families it displays autosomal dominant inheritance