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《医学遗传学 Medical Genetics》课程授课教案(PPT课件讲稿)chapter 2 人类基因 human gene

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Medical Genetics Genes are entities that parents pass to offspring during reproduction.
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Medical Genetics 02人类基因 human gene

Medical Genetics 02 人类基因 human gene

Medical Genetics Genes are entities that parents pass to offspring during reproduction

Medical Genetics Genes are entities that parents pass to offspring during reproduction

Medical Genetics These entities encode information essential for the construction and regulation of proteins(such as enzymes)and other molecules that determine the growth and functioning of the organism

Medical Genetics These entities encode information essential for the construction and regulation of proteins (such as enzymes) and other molecules that determine the growth and functioning of the organism

Medical Genetics 1. Gene Chemistry Composed as a double helix- two linked chemical strands

Medical Genetics 1. Gene Chemistry Composed as a "double helix" - two linked chemical strands

Medical Genetics Linked together by base pairs that can assume one of four variant forms thymine (t) guanine(G) adenine(A) cytosine(C)

Medical Genetics Linked together by base pairs that can assume one of four variant forms: thymine (T) guanine (G) adenine (A) cytosine (C)

Medical Genetics James Watson and Francis Crick display their newly discovered model of DNA, the molecular basis of genetics

Medical Genetics James Watson and Francis Crick display their newly discovered model of DNA, the molecular basis of genetics

Medical Genetics Base sequence form the genetic code that initiates the two major functions of genes: protein systhesis and replication

Medical Genetics Base sequence form the "genetic code" that initiates the two major functions of genes: protein systhesis and replication

Medical Genetics Ser tRNA U C A antic°d。n A G U A C 5 A G U codo mRNA 3' 2nd base in codon uc‖AG Phe Ser Cys IU Phe Ser Leu Ser STOP STOP A Leu Ser STOP Trp 8s苏 Leu Pro His Ar Le Pro His A Leu Pro GIn Arg Leu Pro GIn Arg cAGU lle Thr Asn Ile Thr Asn Ser Ile Thr Lys Arg Met Lys Arg val a Asp Gly cAGUc G V al Ala Asp Gly Val Ala GIu val Ala Glu Gly www.accessexcellence.org/ The genetic code ab/Gg/genetic.html

Medical Genetics

Medical Genetics 2 Gene structure Richard ] roberts and philli A Sharp(1993 Nobel Prize winner) made their amazing discovery of the existence of split genes in the adenovirus, when they examined a hybridized nucleic acid molecule made between a adenoviral mRNA and its template dNa in the electron microscope

Medical Genetics 2. Gene Structure Richard J. Roberts and Phillip A. Sharp (1993 Nobel Prize winner) made their amazing discovery of the existence of split genes in the adenovirus, when they examined a hybridized nucleic acid molecule made between a adenoviral mRNA and its template DNA in the electron microscope

Medical Genetics They observed that the mRNA was much shorter in length and thus was not encoded as an equal colinear segment of the dna molecule. Instead, large loops of unhybridized DNA(A, B and C in figure) were seen. Their interpretation was that the mature messenger rna was derived from four discontinuous segments on the viral dna

Medical Genetics They observed that the mRNA was much shorter in length and thus was not encoded as an equal colinear segment of the DNA molecule . Instead, large loops of unhybridized DNA (A, B and C in figure) were seen. Their interpretation was that the mature messenger RNA was derived from four discountinuous segments on the viral DNA

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