《医学遗传学 Medical Genetics》课程授课教案（PPT课件讲稿）chapter 4 基因突变的分子细胞生物学效应 cellular effects of gene mutation

Medical Genetics 04基因突变的分子 细胞生物学效应 cellular effects of gene mutation

Medical Genetics 04 基因突变的分子 细胞生物学效应 cellular effects of gene mutation

Medical Genetics 1. Genes can be mutated in many ways The most common gene change involves a single base mismatch--a misspelling--placing the wrong base in the DNA. At other times a single base may be dropped or added. And sometimes large pieces of dNa are mistakenly repeated or deleted

Medical Genetics 1.Genes can be mutated in many ways The most common gene change involves a single base mismatch--a misspelling--placing the wrong base in the DNA. At other times, a single base may be dropped or added. And sometimes large pieces of DNA are mistakenly repeated or deleted

Medical Genetics Gene Mutations Mismatch Deletion Repetition Deletion

Medical Genetics

Medical Genetics When a gene contains a mutation, the protein encoded by that gene is likely to be abnormal

Medical Genetics When a gene contains a mutation, the protein encoded by that gene is likely to be abnormal

Medical Genetics DNA→>RNA→> Protein Cell DNA Nucleus membrane Chain of DNA amino bases mRNA acids Gene Protein Ribosome

Medical Genetics

Medical Genetics Altered dNA->Altered Protein cell DNA Nucleus membrane amino or Chain DNA acids bases mRNA Gene 墩 Protein Ribosome

Medical Genetics

Medical Genetics 2. Somatic versus germline mutations Gene mutations can be either inherited from a parent or acquired

Medical Genetics 2. Somatic versus germline mutations Gene mutations can be either inherited from a parent or acquired

Medical Genetics Somatic tissue progeny Germinal tissu Mutant sector Mutant Normal sector Mutant progeny progeny

Medical Genetics

Medical Genetics Hereditary mutations are carried in the dna of the reproductive cells. When reproductive cells containing mutations combine to produce offspring the mutation will be in a of the offspring's body cells

Medical Genetics Hereditary mutations are carried in the DNA of the reproductive cells. When reproductive cells containing mutations combine to produce offspring, the mutation will be in all of the offspring's body cells

Medical Genetics The fact that every cell contains the gene change makes it possible to use cheek cells or a blood sample for gene testing

Medical Genetics The fact that every cell contains the gene change makes it possible to use cheek cells or a blood sample for gene testing