复旦大学：《内科学 Internal Medicine MBBS》课程教学资源（课件讲稿）免疫系统_风湿概论 The Principles of rheumatology

The Principles of Rheumatology Jiang Lindi,Dai Xiaomin Department of Rheumatology Zhongshan Hospital,Fudan University

Jiang Lindi , Dai Xiaomin Department of Rheumatology Zhongshan Hospital, Fudan University The Principles of Rheumatology

"Rheumatology ■ rheuma n first appeared in Hippocratic"in 3rd Century B c A flows as a river or stream A hypothesis of humor tology the study of

“Rheumatology”  rheuma ^ first appeared in “Hippocratic” in 3rd Century B.C. ^ flows as a river or stream ^ hypothesis of humor  tology the study of

History of Rheumatology a 3rd Century B.C.-18th Century: vague 18th Century 1980s systemic diseases 1949, Joseph L Hollander, first use the word"rheumatology treatments: antibioticS, antimalarials, antineoplastics, and anti-immune-rejection drugs ■1980s~ rapidly developing discipline

History of Rheumatology  3rd Century B.C. ~18th Century：vague  18th Century ~ 1980s : systemic diseases 1949, Joseph L. Hollander, first use the word“rheumatology” treatments: antibiotics, antimalarials, antineoplastics, and anti-immune-rejection drugs  1980s ~ rapidly developing discipline

Rheumatology advancements owing largely to new scientific discoveries related to immunology of these disorders a Pathogenesis of many rheumatic diseases are related to immunology and molecular biology The discovery of new biomarkers greatly improve diagnostic efficiency

 advancements owing largely to new scientific discoveries related to immunology of these disorders.  Pathogenesis of many rheumatic diseases are related to immunology and molecular biology.  The discovery of new biomarkers greatly improve diagnostic efficiency. Rheumatology

Rheumatology Most new treatment modalities are also based on clinical research in immunology NSAIDS, GC, DMARDS, biologic agents a Future treatment may include gene therapy as well At present evidence-based medical treatment has helped patients with rheumatic disease lead a near normal life

 Most new treatment modalities are also based on clinical research in immunology : NSAIDs, GC, DMARDs, biologic agents  Future treatment may include gene therapy as well. At present evidence-based medical treatment has helped patients with rheumatic disease lead a near￾normal life Rheumatology

Rheumatic disease a any painful disorder affecting joints, musle connective tissue, soft tissue around the joints and bones connective tissue disease(CTD) is a major focus of rheumatic diseases

Rheumatic Disease  any painful disorder affecting joints, musle , connective tissue, soft tissue around the joints and bones.  connective tissue disease (CTD) is a major focus of rheumatic diseases

The Classification Of Rheumatic Diseases CTD Degenerative: Osteoarthritis Crystal-induced: Gout o rheumatoid arthritis Septic/infectious 口 Lupus erythematosus Congenital and familial disorders a Sjogrens syndrome affecting Joints 口 Scleroderma 口 Marfan syndrome 口 Polymyositis a Ehlers-Danlos syndrome 口 Dermatomyositis SPA( seronegative 口 Vasculitis spondyloarthropathies): d Adult onset still disease ankylosing spondylitis(AS), reactive a Mixed connective tissue arthritis(ReA), psoriatic disease arthritis(PsA), arthropathy of inflammatory bowel disease, undifferential spa

The Classification Of Rheumatic Diseases  CTD  Rheumatoid arthritis  Lupus erythematosus  Sjögren's syndrome  Scleroderma  Polymyositis  Dermatomyositis  Vasculitis  Adult onset still disease  Mixed connective tissue disease  Degenerative：Osteoarthritis  Crystal-induced：Gout  Septic/infectious  Congenital and familial disorders affecting Joints  Marfan syndrome  Ehlers-Danlos syndrome  SPA（seronegative spondyloarthropathies）： ankylosing spondylitis(AS), reactive arthritis(ReA), psoriatic arthritis(PsA), arthropathy of inflammatory bowel disease, undifferential SPA

Normal Diarthrodial Joint What are connective Subchondral Periosteum bone plate Bone Connective tissues are the structu articular cartilage Synovial fluid in joint cavity essentially hold the cells of the bo Joint capsule Muscle These tissues form a framework c Synovium Tendon Examples of connective tissue are Ligament tendons, ligaments, cartilage, bloc and the dermis of the skin Their functions include cushioning, protecting, supporting, insulating and strengthening the body tissues and organs

What are connective tissues ?  Connective tissues are the structural portions of our body that essentially hold the cells of the body together. These tissues form a framework or matrix for the body.  Examples of connective tissue are tendons, ligaments, cartilage, blood, bone, and the dermis of the skin.  Their functions include cushioning, protecting, supporting, insulating and strengthening the body tissues and organs

Connective tissue diseases(CTD Most ctd are autoimmune diseases where auto-bodies attack the normal cells and lead to damage of organ and progressive deterioration of function for the patients

Connective tissue diseases （CTD）  Most CTD are autoimmune diseases where auto-bodies attack the normal cells and lead to damage of organ and progressive deterioration of function for the patients

What causes connective tissue disease? a The specific causes of most CTD are unMown a There are genetic patterns that are considered to increase the risk for developing ctD

What causes connective tissue disease?  The specific causes of most CTD are unknown.  There are genetic patterns that are considered to increase the risk for developing CTD