复旦大学：《内科学 Internal Medicine MBBS》课程教学资源（课件讲稿）内分泌和代谢_Principles of Endocrinology

Principles of endocrinology 凌雁 Yan Ling Department of Endocrinology and metabolism Zhongshan Hospital Fudan University

Principles of Endocrinology Department of Endocrinology and Metabolism Zhongshan Hospital Fudan University 凌 雁 Yan Ling

Scope of endocrinology o Endocrinology is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions called hormones

Scope of endocrinology  Endocrinology is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions called hormones

Function of Endocrine system Endocrine system, composed of endocrine gland (classical) and cells(non-classical), independently or along with nervous system and immune system, coordinate complex body functions, such as metabolism growth and development reproduction etc

Function of Endocrine system  Endocrine system, composed of endocrine gland (classical) and cells (non-classical), independently or along with nervous system and immune system, coordinate complex body functions, such as metabolism, growth and development, reproduction etc

Endocrine glands and organs containing endocrine cels Majar endocine glands: Hypothalamus Pineal gland Pituitary gland Organs containing Thyroid gland endecrine cells Parathyroid glands Thymus Heart Liver Adrena glands stomach Tostes Pancreas Kidney KIdney Small intestine Ovaries

Endocrine glands and organs containing endocrine cells

Endocrine and exocrine Endocrine Endocrine cells Hormone Blood fI。w Endocrine gland Ductless (b) Duct well vascularised Sweat gland長 Exocrine secrete hormones into extracellular fluid or blood

Endocrine and Exocrine Hormone Endocrine cells Duct Sweat gland Endocrine Exocrine -- Ductless -- well vascularised -- secrete hormones into extracellular fluid or blood Endocrine gland

Endocrine, paracrine, autocrine and intracrine Intracrine e Endocrine and neuroendocrine: a chemical released by a specialized Autocrine group of cells into the circulation and acting on a distant target tissue circulation Paracrine Paracrine: chemical communication between neighboring cells within a tissue or Endocrine organ circulation Autocrine a chemical acts on the Endocrine Distant glat same cel target cells e Intracrine: a chemical acting within Neuroendocrine the same cell Neurosecretory ell Distat target cells

 Endocrine and neuroendocrine: a chemical released by a specialized group of cells into the circulation and acting on a distant target tissue.  Paracrine: chemical communication between neighboring cells within a tissue or organ.  Autocrine: a chemical acts on the same cell  Intracrine: a chemical acting within the same cell. Endocrine, paracrine, autocrine and intracrine

Outlines e Part 1: Introduction of hormone Part 2: Hypothalamus, pituitary and their hormones Part 3: Regulation of hormones secretion e Part 4: Endocrine diseases

Outlines  Part 1: Introduction of hormone  Part 2: Hypothalamus, pituitary and their hormones  Part 3: Regulation of hormones secretion  Part 4: Endocrine diseases

Hormone Functional chemical messengers in endocrine system 4 Definition and characteristics Hormone secretion and transport Mechanisms of hormone actions 8?

Functional chemical messengers in endocrine system  Definition and characteristics  Hormone secretion and transport  Mechanisms of hormone actions Hormone

Definition of hormone o Hormone is bioactive chemical messenger released from endocrine cells, and carried by extracellular fluid or blood to target cells throughout the body. By binding to its receptor, hormone initiates multiple reactions

Definition of Hormone  Hormone is bioactive chemical messenger released from endocrine cells, and carried by extracellular fluid or blood to target cells throughout the body. By binding to its receptor, hormone initiates multiple reactions

Characteristics of hormone ◆ Specificity Extracellular Receptor ligand fluid complex ◆ Signaling Membrane ◆ High effective Intracellular ○OO ◆ Cooperation OOOOOOOOOOOOOOOOoO One ligand is amplified into many intracellular molecules

Characteristics of hormone  Specificity  Signaling  High effective  Cooperation