广西医科大学：《生物信息学》第三章 生物信息学网络资源

第三章生物信息学网络资源 (1) NCB简介

第三章 生物信息学网络资源 (1) NCBI简介

National Center for Biotechnology Information(NCBI) www.ncbl.nlm.nih.gov

National Center for Biotechnology Information (NCBI) www.ncbi.nlm.nih.gov

Entrez系统 NcB综合数据库 美国国家生物技术信息中心( Nationa Center for Biotechnology Information, TE 称NCB)创建于1988年。 ●1991年,NCBI开发了 Entrez数据库查询系 统,用于对 Gen Bank等分子生物学和生物 医学文献摘要( Medline)等数据库的查询 ( Schuleret al,1996)

Entrez系统 NCBI综合数据库 ⚫ 美国国家生物技术信息中心(National Center for Biotechnology Information，简 称NCBI）创建于1988年 。 ⚫ 1991年，NCBI开发了Entrez数据库查询系 统，用于对GenBank等分子生物学和生物 医学文献摘要(Medline)等数据库的查询 (Schuler et al, 1996)

Entrez全球搜索引擎 a Entrez cross-database search-Microsoft Internet Explorer 文件(编辑)查看⑩收藏(A)工具①帮助山 中后退·+,③团备搜索收藏夹守媒体④刍·目 地址()圈]hp/www.ncbi.nlmnh.goventrezjIndex.html 转到链接” NCB Entrez, The Life Sciences Search Engine HOME SITE MAPPubMed Entrez Human Genome GenBank Map ViewerBLAST Search across databases IGO CLARHelp Welcome to the new Entrez cross-database search page PubMed: biomedical literature citations D Books: online books and abstracts OMIM: Online Mendelian Inheritance in PubMed Central: free, full text journal articles 大 Man w Site Search: NCBI web and FTP sites 2 Nucleotide: sequence database UniGene: gene-oriented clusters of f transcript sequences Protein: sequence database 2+ CDD: conserved protein domain database 0 Genome: whole genome sequences Structure: three-dimensional

Entrez跨库检索 a cross-database search- Microsoft Internet Explorer 文件(E编辑(查看(收(Δ工具(工帮助H 心后退·+④的备像建宗国收麻夹守媒体③·③囟·回色 地址D)ah: wwncbi.nin rh. powjoqueryioqueryfcg 转到接 NCBI c Entrez, The Life Sciences Search Engine HCME SEARCH SITE MAP PubMed Entrez Human Genome GenBank Map viewer blaSt Search across databases human antioncogene Go Halp 20258 PubMed: biomedical literature citations and abstracts [ 02B Books: online books pubMed Central: tree, tull text 大 OMIM: Online Mendelian 772 heritance in man journal articles 1b86 site search. PcBI web and FTp citeS 288 Nucleotide: sequence database 143615 UniGene: gene-oriented clusters of transcript sequences CDD: conserved protein domain 339 It Genome: whole genome a:G 2n posirunsu domains fromB 57 Structure:three-dimensional n 155142p data UnisT5: markers and mappin macromolecular structres

Entrez用途 检索大分子生物学数据 获取 Gen Bank,EMBL等数据库的核酸序 列 获取 Swiss-port,P|R,PRF,PDB等蛋白质序 列;从核酸序列翻译到蛋白质的序列; 获取基因和染色体图谱;蛋白质三维结构 数据及大分子模式(MDB)等其他生物信 息数据库检索。 PubMed书目文献数据

Entrez系统的使用方法

Entrez系统的使用方法

也址①)ht:ro,nnoy 转到 NCBI National Center for Biotechnology Information National Library of Medicine National Institutes of Health PubMed All Databases BLAST OMIM Books Tax Browser Structure Search All Databases SITE MAP What does ncbi do? Hot spots Resource Guide Established in 1988 as a national resource for b Assembly Archive About NCBI molecular biology information, NCBI create An introduction to public databases, conducts research in Clusters of computational biology, develops software orthologous groups tools for analyzing genome data, and disseminates biomedical information- all for Coffee Break Sequence the better understanding of molecular Genes Disease submission support processes affecting human health and NCBI Handbook and software disease. More P Electronic PCR Literature databases WHole Genome As sociation Entrez Home PubMed, OMIM Books, and The NcBi whole Genome Association(uGA) resource,Entrez Tools I provides researchers with access to genotype an PubMed Central associated phenotype information that will help elucidate the link between genes and disease. For omnibus(GEo) databases release Sequences resources structures, and /AU 1 Bilion Live Traces Influenza virus The Trace Archive of sequencing traces has Resource Genomic reached 1 billion live traces from over 480 biology organisms, For more information about the Trace www.ncbi.nim.nihgov

www.ncbi.nlm.nih.gov

NCBI National Center for Biotechnology Information National Library of Medicin National Institutes of Health PubMed All Databases BLAST OMIM Books Tax Browser Structure Search PubMed Go

NCBI National Center for Biotechnology Information National Library of Medicine ational Institutes of Health PubMed All Databases BLAST OMIMBooks Ta axBrowser Structure Search PubMed All Database integrates the scientific literature DNA and protein sequence databases 3D protein structure data population study data sets assemblies of complete genomes

All Database integrates… • the scientific literature; • DNA and protein sequence databases; • 3D protein structure data; • population study data sets; • assemblies of complete genomes