浙江大学医学院：《药理学》课程教学资源（PPT课件）毒蕈碱受体激动剂 Muscarinic receptor agonists

Muscarinic receptor agonists

Muscarinic receptor agonists

A Muscarinic receptor agonists 口1。 Choline esters碱酯类) 口 Acetylcholine乙酰胆碱 口 Carbachol卡巴胆碱 口 Methacholine醋甲胆碱 口 Bethanechol chloride氯贝胆碱 口2. Natural alkaloids(性物碱类) 口 Pilocarpine毛果芸香碱(匹罗卡品) 口 Muscarine毒_

A Muscarinic receptor agonists 1. Choline esters (胆碱酯类) Acetylcholine 乙酰胆碱 Carbachol 卡巴胆碱 Methacholine 醋甲胆碱 Bethanechol chloride 氯贝胆碱 2. Natural alkaloids (生物碱类) Pilocarpine 毛果芸香碱（匹罗卡品） Muscarine 毒蕈碱

Muscarinic receptor agonists Pilocarpine毛果芸香碱(匹罗卡品) Hs c2 CH2 CH3 Pilocarpine毛果芸香碱

Pilocarpine 毛果芸香碱（匹罗卡品） O N O H5C2 CH2 CH3 H3C H3C H3C N CH2CH2OCOCH3 + ? Pilocarpine 毛果芸香碱 Muscarinic receptor agonists

Muscarinic receptor agonists u 1. Pharmacological effects o(1)Eyes Miosis(缩瞳): contraction of sphincter muscle of iris u Lowing intraocular pressure(降低眼内压): enlarging angle of anterior chamber, increasing drainage of aquous humor Spasm of accommodation(调节癌挛): contraction of ciliary muscle, contraction for near vISIon

1. Pharmacological effects （1）Eyes Miosis（缩瞳）: contraction of sphincter muscle of iris Lowing intraocular pressure（降低眼内压）: enlarging angle of anterior chamber, increasing drainage of aquous humor Spasm of accommodation（调节痉挛）: contraction of ciliary muscle, contraction for near vision Muscarinic receptor agonists

Cornea Iris, cilliary Circular fibers muscles, and (Sphincter, M Lens TIS Schelemm canal Radial fibers Suspensory (Dilator, a) ligaments Circular fibers Ciliary muscles (M Medional fibers Schlemm can Aqueous humor (8) scle

Iris, cilliary muscles, and Schelemm canal

角膜 前睫状静脉 巩膜静脉窦 滤帘 巩膜 前房角 冖虹膜 睫状体 Aqueous humor drainage

Aqueous humor drainage

Cornea Canal of Schlemm Anterior Trabecular meshwork Dilator(a) Sphincter(M) Sclera Iris Lens m() Ciliary muscle(M)

睫状肌松弛 调节于视远物消楚 巩膜静脉窦 扩瞳 悬韧带拉紧 后房 前房 晶状体 Atropine 调节于视近物清楚 虹膜 缩瞳 悬韧带松弛 近物 前房角 睫状肌收缩 Pilocarpine

Pilocarpine Atropine

Muscarinic receptor agonists o(2)Promoting secretion of exocrine ands(外分泌腺体) especially in sweat, salivary and tear glands

（2） Promoting secretion of exocrine glands（外分泌腺体） especially in sweat, salivary and tear glands Muscarinic receptor agonists

Muscarinic receptor agonists 02. Clinical uses o(1) Ophthalmological uses Glaucoma: narrow- or wide-angles Iritis: miotics/mydriatics 口 BOX Glaucoma O Acute congestive glaucoma( narrow-angle) o Chronic simple glaucoma( wide-angle)

2. Clinical uses （1）Ophthamological uses Glaucoma: narrow- or wide-angles Iritis: miotics/mydriatics BOX Glaucoma Acute congestive glaucoma（narrow-angle） Chronic simple glaucoma（wide-angle） Muscarinic receptor agonists