《动物免疫学》课程PPT教学课件（讲稿）体液免疫反应 Humoral Immune Response

Lecture 18 Humoral Immune Response

Lecture 18 Humoral Immune Response

B-cell activation by antigen and helper T cells The Antibody Response B oell cytokines Antibody secretion by plasma cells 名

The Antibody Response

Antibody Protection of the Host Neutralization Opsonization Complement activation complement Antibody prevents Antibody promotes Antibody activates complement. which enhances opsonization bacerial adherence phagocytosis and lyses some bactera @1997 Current Biology Ltd./Garland Publishing,Inc

Antibody Protection of the Host

Immunologic Memory Virgin lymphocyte pool PRIMARY RESPONSE effector cells●●●●DDD0 memory cell pool SECONDARY RESPONSE effector cells memory cell pool ●●●●●●●●●●●IDODOODOOOD

Immunologic Memory Virgin lymphocyte pool PRIMARY RESPONSE SECONDARY RESPONSE effector cells memory cell pool effector cells memory cell pool

Immunologically Naive No previous experience No memory Must be educated

Immunologically Naive No previous experience No memory Must be educated

The Primary Immune Response antibody lag log phase plateau decline titer antigen challenge time

The Primary Immune Response antigen challenge antibody lag log phase plateau decline titer time

Class Switching antibdy titer IgM IgG time

Class Switching antibdy titer time IgM IgG

Four phases of the primary response a lag phase where no antibody is detected a log phase in which the antibody titer rises logarithmically a plateau phase during which the antibody titer stabilizes a phase(decline)during which the antibody is cleared or catabilized

Four phases of the primary response ◼ a lag phase where no antibody is detected ◼ a log phase in which the antibody titer rises logarithmically ◼ a plateau phase during which the antibody titer stabilizes ◼ a phase (decline) during which the antibody is cleared or catabilized

The Anamnestic Immune Response antibody Secondary Response titer 1000 100 Primary 10 Response Time

The Anamnestic Immune Response Time 1 10 100 1000 antibody titer Primary Response Secondary Response

Comparison of Primary and Secondary Responses Time course Antibody titer Antibody class Antibody affinity

Comparison of Primary and Secondary Responses ◼ Time course ◼ Antibody titer ◼ Antibody class ◼ Antibody affinity