河北医科大学：《天然药物化学》课程教学资源（课件讲稿）第十一章 天然药物研究与开发（2020版）1/6

第11章天然药物的研究开发 天然药物化学学习了那些内容？这门课重要吗？ 能不能从天然产物中开发药物？为什么？ 从天然产物中开发了那些药物？ 如何从天然产物中开发药物？程序？我们这门课如 何发挥作用？ 天然药物的历史多久？有哪些经典的案例？对哪些 疾病的药物开发中表现较为突出？ 我国天然药物化学研究的历史有多久？代表性人物？

天然药物化学 1.总论 2. 糖和苷 生物活性 结构特征 3. 苯丙素类 4. 醌类化合物 5. 黄酮类化合物 生物合成 化学成分 理化性质 6. 萜类和挥发油 7.三萜及其苷类 主要类型 8. 甾体及其苷类 9. 生物碱 结构测定 提取分离 10.海洋药物

What Have We Learned? What are Alkaloids? Primary Metabolism? Flavonoids? Primary Metabolites? Coumarins? Secondary Metabolites? Terpenoids? Lead compound? Lignans? Biosynthesis? Anthraquinones? Biogenetic Isoprene Rule? Cardiac Glycosides? Glycosides? Iridoids?Volatile Oil? Azulenoids?

What's in common of these Compounds AcO Me Me OH HO. NH Me Me H3CO OH HO H HO OBz OAc 吗啡morphine 奎宁quinine 紫杉醇Taxol HO MeO- CH3 H H H H3C- C-NH- OH MeO】 CH3 COOH Penicillin OMe 青蒿素 青霉素 雷帕霉素

Why Fleming Did not Isolated Penicillin Fleming would not have received the Nobel Prize if not a mould accidently entered his laboratory.Did Alexander Fleming Deserve the Nobel Prize? Penicillin G Alexander Fleming Dorothy C.Hodgkin 1881-1955 1945 Nobel Prize (1910-1994) 1945 Nobel Prize 1964 Nobel Prize in Medicine 晶体王国之花 6

CLE Google commemorated Hodgkin's 104th birthday,May 12,2014 Sir Robert Robinson did not like the B-lactam structure because this would be unstable,unlike penicillin.They were taken aback when a young woman... John W.Cornforth said "If penicillin turns out to have the B-lactam structure I shall give up chemistry and grow mushrooms."He did not keep his threat but later received a Nobel prize for his enzyme work 30 years later

Insulin-A Storytelling Molecule 一个大创学生如何做出了诺贝尔奖级的成果？ Dorothy C.Hodgkin Frederick Banting and Frederick Sanger 1910-1994,1964NP Charles Best with one of 1918-2013,1958NP the first diabetic dogs to The human insulin receive insulin,1923 NP protein is composed of 51 amino acids

Are Natural Products Important? Significance and Impact AcO 0 Me Me OH Ph NH Me Me CH. O HO H HO OBz OAc 吗啡morphine 紫杉醇Taxol Natural products are central to biology and medicine, serving as pharmaceutical leads,drugs,and powerful reagents for studying cell biology

阿北医绛大学 HEBEI MEDICAL UNIVERSITY 天然药物化学 Medicinal Natural Product Chemistry What are they?What have we learned? Where can you find them? What can you do with them? What we need to know?What we did not know? Most Important Natural Medicine Includeding.....?

天然药物化学 一天然药物是什么？ —天然药物化学是什么时候产生的？ —天然药物和我们人类的发展及现实生活有什么关系？ 天然药物化学和有机化学、药物化学、药理学、毒理学有什么联系？ 天然药物化学和药物的研发有什么关系？ 青霉素、链霉素、青蒿素、吗啡、阿司匹林、紫杉醇、避孕药、维 生素等天然药物或与天然药物密切相关的这些药物是在什么背景下 发现的？ 一为什么含有皂苷的药物不宜静脉给药？ 一为什么大豆富含的大豆异黄酮有雌激素样作用？ 为什么路边的夹竹桃很少有虫害，牲畜也避而远之？