复旦大学：《医学遗传学 Medical Genetics》课程教学资源（学习报告）Asthma and Eczema

ASTHMA ECZEMA Michael Widjaja 08301016030 黄合乐

ASTHMA, ECZEMA Michael Widjaja 08301016030 黄合乐

UTlIne 口 Preconceived notions a How allergic asthma is triggered 口 Mechanism of asthma a Methods of treatment of asthma o Factors that lead to asthma 口 Eczema and the factors that lead to计 o Link between asthma and eczema 口 Conclusion

Outline  Preconceived notions  How allergic asthma is triggered  Mechanism of asthma  Methods of treatment of asthma  Factors that lead to asthma  Eczema and the factors that lead to it  Link between asthma and eczema  Conclusion

Initial thoughts on asthma n Asthma causes difficulty in breathing 口 Consists of two parts a Constriction of bronchi a Overproduction of mUcuS in respiratory tract 口 Caused by 口 Allergies a Drastic change in temperature a Exercise a Heritable family history

Initial thoughts on asthma  Asthma causes difficulty in breathing  Consists of two parts  Constriction of bronchi  Overproduction of mucus in respiratory tract  Caused by  Allergies  Drastic change in temperature  Exercise  Heritable? family history

Initial thoughts on Eczema a Dry itchy skin, redness, cracking, oozing or bleeding n causes 口 Allergies a Skin Irritants a Dry weather a Sweat n Eczema linked to asthma in some way a Genetically linked disease?

Initial thoughts on Eczema  Dry itchy skin, redness, cracking, oozing or bleeding  Causes  Allergies  Skin Irritants  Dry weather  Sweat  Eczema linked to Asthma in some way  Genetically linked disease?

Anatomy of Asthma moored at个 expired a Anatomy of an Asthma Attack primary breech larynx (voice boo) trachea (windpipe) rgnt lng left wng bronotxlos ranchi tube biood vesels filtrated by inflammation mmre cels and selling decre→sed contr acted lmon smooth esoo mcu amooth Dood vessels lumen 6 2001 Encyclopaedia Britannica, ino normal airway bstruoted airway

Anatomy of Asthma

Triggers of Asthma Dust 口 Pollen 口 Cockroaches 口 Cold air a Smoke a Animal dander, skin dried saliva, hair

Triggers of Asthma  Dust  Pollen  Cockroaches  Cold air  Smoke  Animal dander, skin, dried saliva, hair

Mast cells and plasma Cells Muscle cell Blood vessel Plasma cells he Villar epitheliu

Mast Cells and Plasma Cells

Mechanism of asthma 口 Antigen enters body n Plasma cell produce immunoglobulin e(lge d ige binds to surface of mast cells n Future exposures to antigen results in binding of antigen to surface bound igE a Mast Cells degranulate releasing Histamine and Leukotriene

Mechanism of Asthma  Antigen enters body  Plasma cell produce immunoglobulin E(IgE)  IgE binds to surface of mast cells  Future exposures to antigen results in binding of antigen to surface bound IgE  Mast Cells degranulate releasing Histamine and Leukotriene

Mast Cell degranulation Adenylate cyclase Fusion of granules Micro filaments ECF-A

Mast Cell Degranulation

Steroid effects of the lung a Leukotriene promotes contraction of smooth muscle of the bronchioles n Histamine increases vascular permeability, causing capillary eakage and edema Why asthma makes it hard to breathe ed bronchial tube Normal bronchial tube

Steroid effects of the lung  Leukotriene promotes contraction of smooth muscle of the bronchioles  Histamine increases vascular permeability, causing capillary leakage and edema