北京化工大学：《化工原理》课程教学资源（专题讲稿）Modern Drug Delivery Technologies and Their Applications with Nanomaterials

Drug Release

2 Drug Release Drug Release

CONTENTS >Introduction of modern drug delivery Controlled drug release and targeted drug delivery ·Concept and history Advantages and disadvantages >Principles of controlled release Methods of controlled release Release kinetics of controlled release

3 ¾Introduction of modern drug delivery Introduction of modern drug delivery • Controlled drug release and targeted drug delivery • Concept and history • Advantages and disadvantages ¾Principles of controlled release • Methods of controlled release • Release kinetics of controlled release CONTENTS CONTENTS

CONTENTS >Principles of targeted drug delivery Design of targeted drug delivery Methods of targeted drug delivery >Applications of nanomaterials in controlled release Structure design and synthesis Loading of active materials Application examples

4 ¾Principles of targeted drug delivery • Design of targeted drug delivery • Methods of targeted drug delivery ¾Applications of nanomaterials in controlled release • Structure design and synthesis • Loading of active materials • Application examples CONTENTS CONTENTS

Introduction of modern drug delivery Traditional drug delivery ● Oral Injection Inhaler Skin n0a量

5 Introduction of modern drug delivery Traditional drug delivery • Oral • Injection • Inhaler • Skin • ……

The Mist,The Spray The Dust

6 The Mist, The Spray & The Dust The Mist, The Spray & The Dust…

Introduction of modern drug delivery Disadvantages of traditional drug delivery ·Not site-specific Waste of drug Side effects (even toxic)to other organs Inconvenient administration ·Etc

7 Disadvantages of traditional drug delivery • Not site-specific • Waste of drug • Side effects (even toxic) to other organs • Inconvenient administration • Etc. Introduction of modern drug delivery

Introduction of modern drug delivery Drug administration has developed rapidly as significant progress being made in the research activities of materials science and engineering. Two major breakthroughs include: controlled drug release targeted drug delivery

8 Drug administration has developed rapidly as significant progress being made in the research activities of materials science and engineering. Two major breakthroughs include: • controlled drug release • targeted drug delivery Introduction of modern drug delivery

Controlled Release

9 Controlled Release Controlled Release

Controlled drug release Efforts to use materials to regulate the spatial and temporal release of substances for a agricultural, veterinary,cosmetic, medicinal and household applications are probably as old as mankind

10 Efforts to use materials to regulate the spatial and temporal release of substances for agricultural, veterinary, cosmetic, medicinal and household applications are probably as old as mankind. Controlled drug release Controlled drug release

Controlled drug release Concept Controlled release is the field of scientific activity concerned with the control in time and space of the biological effects of therapeutic agents in human and animal health,and of other active agents in environmental,consumer and industrial applications

11 ¾ Concept Controlled release is the field of scientific activity concerned with the control in time and space of the biological effects of therapeutic agents in human and animal health, and of other active agents in environmental, consumer and industrial applications. Controlled drug release Controlled drug release