西南大学药学院：固体制剂（Solid preparation）片剂

Chapter 6 Solid preparation Dr Lei luo 国)兽医 Southwest University College of Pharmeceutical Sciences and Chinese Medicine 15730075066@sina.cn

Chapter 6 Solid preparation Dr. Lei Luo 15730075066@sina.cn

Requirements (1)To understand the definition, characteristics and preparation methods of powders, granules, capsules, drops and pills (2)Master the preparation process, influencing factors and quality control of granules and capsules (3)Master the prescription design of tablets, the classification and application of excipients, the process and equipment of tableting (4)Master the quality evaluation of tablets

Requirements (1) To understand the definition, characteristics and preparation methods of powders, granules, capsules, drops and pills. (2) Master the preparation process, influencing factors and quality control of granules and capsules; (3) Master the prescription design of tablets, the classification and application of excipients, the process and equipment of tableting; (4) Master the quality evaluation of tablets

Contents Powders 2 Granules Capsules 4 Tablets 5 Drops and films

Contents 1 Powders 2 Granules 3 Capsules 4 Tablets 5 Drops and films

Solid preparation producing flow chart Process Flow Diagram For Tablet IC Pharma Group Powders Capsules Granules Tablets eG非 dary Material Direction or Prae

Solid preparation producing flow chart Powders Granules Capsules Tablets

1 Powders 1.1 Definition Powders are mixtures of dry, fine, divided drugs and/or chemicals that may be intended for internal (oral)or external(topical) use May be intended for internal use or external use, but most frequent use is external Use as a dosage form is limited but use in preparation of other dosage forms is extensive

1. Powders 1.1 Definition Powders are mixtures of dry, fine, divided drugs and/or chemicals that may be intended for internal (oral) or external (topical) use. • May be intended for internal use or external use, but most frequent use is external. • Use as a dosage form is limited, but use in preparation of other dosage forms is extensive

Noyes-Whitney equation Dissolution rate dc/dt=Ks(Cs℃)K=D/8 K- dissolution rate constant S-surface area of undissolved solid D-diffusion constant of drug Cs- solubility in dissolution medium 0- Thickness of boundary layer C-concentration in medium V-Volume of dissolution medium

Noyes-Whitney equation Dissolution rate: dC/dt=KS (CS -C) K=D/Vδ K- dissolution rate constant S- surface area of undissolved solid D- diffusion constant of drug CS - solubility in dissolution medium δ- Thickness of boundary layer C- concentration in medium V- Volume of dissolution medium

Lactose(30-60p 1.2 Adm 10μ Intal a)Oral: oral Cromolyn Sodium(2-6u b)Inhalation c)Nasal d)Topical: large open wound e)Ear powder f) Preparing for further treatment: suspension. syrup, oral drops, injection

1.2 Administration routes a) Oral: oral powders, effervescent powders b) Inhalation: dry-powder as pulmonary DDS c) Nasal d) Topical: large open wound e) Ear powder f) Preparing for further treatment: suspension, syrup, oral drops, injection

1.3 Advantages and disadvantages a) Chemically stable and long shelf-life b) convenient for patients c)Orally powders fast dissolution d) Topical powders large spread area

1.3 Advantages and disadvantages a) Chemically stable and long shelf-life b) Convenient for patients c) Orally powders fast dissolution d) Topical powders large spread area

1.3 Advantages and a)Less convenient than tablets or capsules b) Hard to mask unpleasant taste c)Difficult to protect from atmospheric moisture or oxygen d)Not suitable for low dose(difficult measurement) e)Not suitable for drugs irritate or damage stomach

1.3 Advantages and disadvantages a) Less convenient than tablets or capsules b) Hard to mask unpleasant taste c) Difficult to protect from atmospheric moisture or oxygen d) Not suitable for low dose (difficult measurement) e) Not suitable for drugs irritate or damage stomach

Divided Powders Have generally fallen into disuse because of the ready availability of tablets and capsules Some commercial OTC products are packaged in similar unit-dose packets -BC Headache Powders -Stanback Analgesic Powders

Divided Powders • Have generally fallen into disuse because of the ready availability of tablets and capsules. • Some commercial OTC products are packaged in similar unit-dose packets: –BC Headache Powders –StanbackAnalgesic Powders