广州医科大学（广州医学院）：《病理学》课程教学资源（PPP课件，双语版）Chapter 6 Rheumatic fever（RF）

Liuyisheng

Aorta Arteries Vein Large- vessei Vasculitis (e. g Arteriole Venule giant-cell arteritis. Takayasu arents Medium-Sized Capillary Vessel Vasculitis (e. g. polyarteritis nodosa Kawasaki disease) Goodpasture syndrome Small- Vessel Vascuhts (e.g. microscopic polyangitis, Wegener granulomatosis) Isolatec cutaneous LCA Henoch-Schonlein purpura and abutne mio vasculitis Microscopic polyangitis, Wegener granulomatosis and Churg Strauss syndrome

The cardiovascular system is composed of heart, arterials capillaries and veins It is the structure foundation for keeping blood circulation material exchanges between blood and tissue and transmitting nformation of body fluid Normal heart

◼ The cardiovascular system is composed of heart, arterials, capillaries and veins. It is the structure foundation for keeping blood circulation, material exchanges between blood and tissue and transmitting information of body fluid. Normal heart

The structure changes of cardiovascular system will be responsible for the functional changes that disturb whole and or local blood circulation The disorders of cardiovascular system affect the human health and life and are a leading cause of death in the world The valve of normal heart

◼ The structure changes of cardiovascular system will be responsible for the functional changes that disturb whole and/or local blood circulation. The disorders of cardiovascular system affect the human health and life and are a leading cause of death in the world. The valve of normal heart

Mainly discuss the commonest diseases of heart and arterials including ① degenerative vascular disorders including atherosclerosis, hypertension 2ischemic heart disease including myocardial infarction myocarditis and cardiomyopathy diseases of the pericarditis; ⑤ rheumatic fever; infective endocarditis (disorder of cardiac valves

Mainly discuss the commonest diseases of heart and arterials, including : ◼ ①degenerative vascular disorders including atherosclerosis, hypertension; ◼ ②ischemic heart disease including myocardial infarction; ◼ ③myocarditis and cardiomyopathy； ◼ ④diseases of the pericarditis； ◼ ⑤rheumatic fever； ◼ ⑥infective endocarditis； ◼ ⑦disorder of cardiac valves

Rheumatic fever (RF) a This is a multisystem disease and an acute, often recurrent, inflammatory disease principally of children that generally follows a pharyngeal(but not skin) infection with group a beta-hemolytic streptococci

Rheumatic fever (RF) ◼ This is a multisystem disease and an acute, often recurrent, inflammatory disease principally of children that generally follows a pharyngeal(but not skin) infection with group A beta-hemolytic streptococci

immune response throat Lymph node B lymphocytes Antistrep B-hemolytic antibodies streptococcu ACUTE RHEUMATIC HEART DISEASE CROSS-REACTIONS Vegetations Myocardial Aschoff body Fibrinous pencarditis

RF is a systemic disorder affecting Heart: pericarditis, myocarditis, and endocarditis, joint: polyarthritis skin: subcutaneous nodules and erythema ④ arteries: arteritis

◼ RF is a systemic disorder affecting: ◼ ①heart: pericarditis, myocarditis, and endocarditis; ◼ ②joint: polyarthritis; ◼ ③skin: subcutaneous nodules and erythema; ◼ ④arteries: arteritis

Aschoff bodies constitute foci of fibrinoid necrosis surrounded by lymphocytes macrophages, an occasional plasma cell and plump"activated "histiocytes called Anitschkow cells or aschoff cells lesions stimulate fibroblast proliferation and lead to scarring

◼ Aschoff bodies constitute foci of fibrinoid necrosis surrounded by lymphocytes, macrophages, an occasional plasma cell, and plump “activated” histiocytes called Anitschkow cells or Aschoff cells. Lesions stimulate fibroblast proliferation and lead to scarring

Aschoff nodule at high magnification. The most characteristic component is the Aschoff giant cell. Several appear here as large cells with two or more nuclei that have prominent nucleoli

Aschoff nodule at high magnification. The most characteristic component is the Aschoff giant cell. Several appear here as large cells with two or more nuclei that have prominent nucleoli