《皮肤性病学》课程教学课件（PPT讲稿）Herpes Zoster（带状疱疹）课件

ZosterHerpes业蓝W

Herpes Zoster

DefinitionHerpesiscausedzosterby(VZV)Varicella - Zosterviruswithinclassicallyunilaterallyoccursthe distribution of asensorynerve.beingbyclusteredcharacterizedandvesiclesconsiderableneuralgia

Definition Herpes zoster is caused by Varicella - Zoster virus (VZV) , classically occurs unilaterally within the distribution of a sensory nerve, being characterized by clustered vesicles and considerable neuralgia

Pathogen and PathogenesisPathogen(VZV)Varicella-Zoster1SViruscharacterizedneurotropism andbydermatotropismHOUSE

Pathogen and Pathogenesis Pathogen Varicella-Zoster virus (VZV) is characterized by neurotropism and dermatotropism

PathogenesisVZVI the primary infectionnonimmune hostvaricellaVZV establishesganglialatencyinsensoryI the declinefunctioninimmuneVZVreplicate latermayHerpeszostershowingandclusteredvesiclesneuralgia

Pathogenesis VZV ↓ the primary infection nonimmune host ↓ varicella ↓ VZV establishes latency in sensory ganglia ↓ the decline in immune function VZV may replicate later ↓ Herpes zoster showing neuralgia and clustered vesicles

The incidence of herpeszosterwithandadvancingincreasesagedecline in immunefunctionOtherthanimmunosuppressionandinvolvedinage, the factorsunknownreactivationare

The incidence of herpes zoster increases with advancing age and decline in immune function. Other than immunosuppression and age, the factors involved in reactivation are unknown

Clinical manifestationsProdrome:feverheadache andhyperaesthesiapain in the affectedarea

Clinical manifestations Prodrome: ⚫ headache and fever ⚫ hyperaesthesia ⚫ pain in the affected area

Features of lesionsinitiallyas papules and plaquespresentsof erythemaredofclusteredpapules formcropsbanddiscontinuousainevolvevesiclesto clearsurroundedbyerythema

Features of lesions ⚫ initially presents as papules and plaques of erythema ⚫ crops of clustered red papules form in a discontinuous band ⚫ evolve to clear vesicles surrounded by erythema

theyhave feweruptionmaylesionsor reachtotal confluencein thedermatomebecomehemorrhagiclesionsmay bullousnecrotic, or

⚫ the eruption may have few lesions or reach total confluence in the dermatome ⚫ lesions may become hemorrhagic, necrotic, or bullous

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Herpes zoster