《糖生物学》课程教学课件（讲稿）01 concept

The concept of Glycochemistryand Glycobiology1

The concept of Glycochemistry Glycochemistry and Gly gy cobiology 1

References☆"CarbohydrateChemistry"Benjamin G.DavisOxford UniversityPress 2002☆"Introduction to Glycobiology"2nd Ed.MaureenE.TaylorOxfordUniversityPress2003☆“Biochemistry"Garrett,4thEd.2008☆A varieties of papers"Essentials of Glycobiology"2nd Ed.AjitVarki2009“Functional and Molecular Glycobiology"BiOSscientificpublishers20022

“C b h d “Carbohydrate Ch i ” em stry” Bj i en am n G. D i av s Oxford University Press 2002 “Introduction to Glycobiology” 2nd Ed. Maureen E. Taylor Oxford University Press 2003 “Biochemistry” Garrett, 4th Ed. 2008 A varieties of p pa ers “Essentials of Glycobiology” 2nd Ed. Ajit Varki 2009 “Functional and Molecular Glycobiology” BIOS scientific publishers 2002 2

OutlineThe concept of glycochemistry and glycobiologyFischer Projection and the story behind*Open chain and ring structure ofmonosaccharidesReactions of the hydroxyl groupsReactionsoftheanomericcentreClassical Polysaccharides/as biocompatiblematerials*The development of Lock-key concept*N-linked glycosylation3

™The concept concept of glycochemistry glycochemistry and glycobiology glycobiology ™Fischer Projection and the story behind ™Open chain and ring structure of monosaccharides ™Reactions of the hydroxyl groups ™Reactions Reactions of the anomeric anomeric centre ™Classical Polysaccharides/as biocompatible materials ™The development of Lock‐key concept ™N‐linked glycosylation 3

Outline*O-linked glycosylationGlycolipid and membrane protein glycosylationModern chemical and chemoenzymatic synthesisof oligosaccharides*Effect of glycosylation on protein structure andfunctionCarbohydrate recognition in cell adhesion andsignaling*Cyclodextrins/ourresearch*Update and Outlook

™O‐linked glycosylation ™Glycolipid and membrane protein glycosylation ™Modern chemical chemical and chemoenzymatic chemoenzymatic synthesis synthesis of oligosaccharides ™Effect of gl li ycosylation on protein structure and function ™Carbohydrate recognition in cell adhesion and signaling ™Cyclodextrins/our research ™Update and Outlook 4

HOCH2CH,OHOHOHHHHOHHCH,OHOHHHoOHOHHHOHfructoseglucoseCH,OH0HOCHHHOH送私吃HOHHHHOHo1COHOHHOHsucrose

LactoseAmyloseAmylopectinXanthan gumCH2OHHOHSFCOOHRHgCOOHHOOH

CelluloseOHHH

Cellulose

CH301NHHOHOCNHOHOCH3n.Chitin

Chitin

HCHHOHOHOHOOHOHHOMeMeMeHOOHMeMeHOMeMeMeMeHOHMeHOHOHOHOMeMeHOOHOOHHOHOOHRb,Ginsengoside

9

OHOHHOHHCOH1OHn2HOHOHOHOHOHOOHHOOHHOHOOHOHOHHOHOHOOHHOOHOHOHOHn

OH O O OH O OH HO OH O OH O OH O HO OH HO O O OH HO O O OH n OH O HO O OH HO O OH n O HO n HO HO OH HO HO O OH HO HO HO OH O O OH HO O OH HO O O HOO O OH HOO O HO HO HO O O OH HO O O OH n HO O O OH HO O OH O OH OH